George Wells Beadle
(born Oct. 22, 1903, Wahoo, Neb., U.S. — died June 9, 1989, Pomona, Calif.) U.S. geneticist. He earned his Ph.D. from Cornell University. While studying
Drosophila, he realized that genes must influence heredity chemically and designed a complex technique to determine the nature of those effects, showing that something as apparently simple as eye colour results from a long series of chemical reactions, which are affected by genes. With
Edward L. Tatum, he found that the total environment of a bread mold could be varied so that researchers could locate and identify mutations relatively easily, concluding that each gene determines the structure of a specific enzyme, which in turn allows a single chemical reaction to proceed. For the "one gene, one enzyme" concept, they shared a 1958 Nobel Prize with
Joshua Lederberg. Beadle later served as president of the University of Chicago (1960 – 68).
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