Gitelman's syndrome is a rare and mild inherited defect in the distal convoluted tubule of the kidneys caused by a defect in the kidney's ability to reabsorb magnesium, sodium, potassium, and chloride into the bloodstream. This is due to a mutation in the gene that codes for one of the electrolyte co-transporters in the kidney. The absence of this co-transporter may account for surplus loss of magnesium and potassium and insufficient secretion of calcium from the kidneys.
Symptoms of Gitelman's syndrome include excessive urination, excessive thirst, low blood sodium level, low blood magnesium level, salt craving, muscle cramps, muscle weakness, fatigue, dizziness, nocturia, polydipsia and many more.