| Dental Dictionary: glycopyrrolate |
trade names: Robinul, Robinul Forte; drug class: anticholinergic; action: inhibits acetylcholine at receptor sites in autonomic nervous system, which controls secretions, free acids in stomach; uses: decreased secretions before surgery, reversal of neuromuscular blockade, peptic ulcer disease, irritable bowel syndrome.
| 5min Related Video: Glycopyrrolate |
| Drug Info: Glycopyrrolate |
Brand names: Robinul®Robinul® Forte
Chemical formula:
Glycopyrrolate tablets
What are glycopyrrolate tablets?
GLYCOPYRROLATE (Robinul®) helps relieve spasms in the stomach and bowel. It helps treat peptic ulcer disease or irritable bowel syndrome. Generic glycopyrrolate tablets are not yet available.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
• difficulty passing urine
• glaucoma
• heart disease or irregular heartbeat
• hiatal hernia
• high blood pressure
• intestinal problems
• kidney disease
• myasthenia gravis
• nervous system disease
• over active thyroid
• stomach obstruction
• ulcerative colitis
• an unusual or allergic reaction to glycopyrrolate, other medicines, foods, dyes, or preservatives
How should I take this medicine?
Take glycopyrrolate tablets by mouth. Follow the directions on the prescription label. Swallow the tablets with a drink of water. Take your medicine at regular intervals. Do not take your medicine more often than directed.
Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.
What drug(s) may interact with glycopyrrolate?
• bethanechol
• cisapride
• disopyramide
• donepezil
• erythromycin
• galantamine
• medicines for hay fever and other allergies
• medicines for mental depression
• medicines for mental problems and psychotic disturbances
• metoclopramide
• rivastigmine
• tacrine
• tegaserod
Tell your prescriber or health care professional about all other medicines you are taking, including nonprescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.
What should I watch for while taking glycopyrrolate?
You may get drowsy, dizzy, or have blurred vision. Do not drive, use machinery, or do anything that needs mental alertness until you know how glycopyrrolate affects you. To reduce the risk of dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. Alcohol can make you more drowsy, avoid alcoholic drinks.
Avoid extreme heat (e.g., hot tubs, saunas). Glycopyrrolate can cause you to sweat less than normal. Your body temperature could increase to dangerous levels, which may lead to heat stroke.
Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water will help.
If you get constipation while receiving glycopyrrolate, do not treat yourself. You may have a blockage in the intestine. Call your prescriber or health care professional for advice.
What side effects may I notice from taking glycopyrrolate?
Side effects that you should report to your prescriber or health care professional as soon as possible:
• agitation, nervousness, confusion
• blurred vision and other eye problems
• decreased sweating
• dizziness, drowsiness
• irregular heartbeat (palpitations)
• pain or difficulty passing urine
• unusual weakness or tiredness
• vomiting
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• constipation
• difficulty sleeping
• dry mouth, change in taste
• headache
• nausea
• sexual difficulty (impotence)
Where can I keep my medicine?
Keep out of the reach of children in a container that small children cannot open.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.
Last updated: 7/1/2002
Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.
| Medical Dictionary: gly·co·pyr·ro·late |
A parasympatholytic compound used as premedication to general anesthesia, as an antagonist to the bradycardic effects of neostigmine during curare reversal, and as an adjunct in the treatment of peptic ulcer.
| Wikipedia: Glycopyrrolate |
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|
| Systematic (IUPAC) name | |
|---|---|
| 3-(2-cyclopentyl-2-hydroxy-2-phenylacetoxy)-1,1-dimethylpyrrolidinium | |
| Identifiers | |
| CAS number | 596-51-0 |
| ATC code | A03AB02 |
| PubChem | 3494 |
| DrugBank | APRD01000 |
| Chemical data | |
| Formula | C19H28NO3+ |
| Mol. mass | 318.431 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | 0.6–1.2 hours |
| Excretion | 85% renal, unknown amount in the bile |
| Therapeutic considerations | |
| Pregnancy cat. |
B |
| Legal status | |
| Routes | oral, IV |
 (what is this?) (verify) |
|
Glycopyrrolate is a medication of the muscarinic anticholinergic group. It is a synthetic quaternary amine with no central effects and is available in oral and intravenous (i.v.) forms.
With counterion, it is known as glycopyrronium bromide.[1]
Contents |
Glycopyrrolate blocks muscarinic receptors,[2] thus inhibiting cholinergic transmission.
In anesthesia, glycopyrrolate injection can be used as a preoperative medication on order to reduce salivary, tracheobronchial, and pharyngeal secretions, as well as decreasing the acidity of gastric secretion. It is also used in conjunction with neostigmine, a neuromuscular blocking reversal agent, to prevent neostigmine's muscarinic effects such as bradycardia.
It is also used to reduce excessive saliva (sialorrhea).[3][4][5]
It decreases acid secretion in the stomach and so may be used for treating stomach ulcers, in combination with other medications.
Use in treating asthma[6][7] and COPD[8] has been described.
It has been used topically and orally to treat hyperhidrosis.[9][10]
Since glycopyrrolate reduces the body's sweating ability, it can even cause fever and heat stroke in hot environments. Dry mouth, difficulty urinating, headaches, diarrhea and constipation are also observed side effects of the medication.
The medication also induces drowsiness or blurred visions, an effect exacerbated by the consumption of alcohol.
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 | Dental Dictionary. Mosby's Dental Dictionary. Copyright © 2004 by Elsevier, Inc. All rights reserved. Read more |
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| Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved. Read more |
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| Medical Dictionary. The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Read more |
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| Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Glycopyrrolate". Read more |
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