Ape (the animal) is simio or mono. Ape as a description of a big uncouth person, is bruto or bruta. Ape, used affectionately (or not) in "You big ape!, is "Pedazo de bruto!" or "Animal!" Ape, the verb, as in "to ape his manerisms" is imitar. Ape, as in "to go ape" (ie crazy) is "ponerse como loco"