If by "artificial gender" you mean grammatical gender, the answer is no. Many languages do without grammatical gender, for example Chinese and the made-up language Esperanto. Remember that grammatical gender is utterly unrelated to physical gender: it is all about the form of the word, not the meaning.

Sentences don't have gender. In English, pronouns have grammatical gender (she is feminine, he is masculine, it is neuter).

In Latin, it is marked masculine. In English, there is no grammatical gender.

personel pronouns

Neither. English nouns do not have grammatical gender.