Granuloma inguinale is a sexually transmitted infection that affects the skin and mucous membranes of the anal and genital areas.

The most significant distinguishing characteristic of granuloma inguinale is the skin ulcer, which is larger than in most other diseases, painless, irregular in shape, and likely to bleed when touched.

Granuloma inguinale is spread primarily through heterosexual and male homosexual contact; however, its occurrence in children and sexually inactive adults indicates that it may also be spread by contact with human feces.

Most patients with granuloma inguinale recover completely, although superinfected ulcers may require lengthy courses of medication. Early treatment prevents the complications associated with second- and third-stage infection.

Rod-shaped oval organisms found in tissue samples from patients with granuloma inguinale. Donovan bodies appear deep purple when stained with Wright's stain.