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hantavirus

  (hăn'tə-vī'rəs) pronunciation
n.

Any of a group of viruses carried by rodents that cause epidemic hemorrhagic fever and severe respiratory infections in humans.

[After the Hantan River, South Korea (near which Westerners were first infected by the virus in the 1950s).]


 
 

Genus of viruses of the family Bunyaviridae that cause pneumonia and hemorrhagic fevers. Carried by rodents, they spread to humans directly or by inhalation but apparently are not transmitted from one person to another. An outbreak in the 1990s in the southwestern U.S. caused a mysterious, often fatal, flulike illness with rapid respiratory failure in previously healthy adults. The culprit was a hantavirus type carried by mice and not previously associated with human illness in the U.S.

For more information on hantavirus, visit Britannica.com.

 

Hantavirus refers both to a family of biological viruses that can be transmitted from animals to humans and to hantavirus pulmonary syndrome—the highly fatal infection caused by the viruses. Most often transmitted by exposure to the droppings of rodents, especially deer mice, infected individuals experience fever, nausea, vomiting, muscle and head aches, and, if left untreated, respiratory distress that can result in death. Other hantaviruses produce kidney disease.

As of 2003, an effective treatment for hantavirus was not yet available. Although long recognized in other countries, the disease was fairly rare in the United States, and the likelihood of infection was low. The first outbreak in the United States occurred in May 1993 in the Four Corners area of Arizona, Colorado, New Mexico, and Utah, and by April 2001, 283 cases of the disease had been reported in thirty-one states.

Bibliography

Hjelle, B., S. Jenison, G. Mertz, et al. "Emergence of Hantaviral Disease in the Southwestern United States." Western Journal of Medicine 161, no. 5 (1994): 467–473.

Schmaljohn, C. S., and S. T. Nichol, eds. Hantaviruses. Berlin and New York: Springer Verlag, 2001.

 
any of a genus (Hantavirus) of single-stranded RNA viruses that are carried by rodents and transmitted to humans when they inhale vapors from contaminated rodent urine, saliva, or feces. There are many strains of hantavirus. The first to be isolated (1976) was the Hantaan virus (from the Han River in South Korea, which also gives the species its name). Hantaan virus and its related strains, Seoul virus and Puulmala virus, cause Korean hemorrhagic fever (more correctly, “hemorrhagic fever with renal syndrome”), a condition in which the capillaries of the circulatory system begin to leak blood. Although some people with the disease are nearly asymptomatic, in others it can lead to shock, acute kidney failure, and, in 10% of cases, death.

A second disease, hantavirus pulmonary syndrome, was identified in the United States in 1993 and is caused by at least three strains of the virus. It is known to be carried by deer mice, white-footed mice, and cotton rats. This disease is much more deadly, causing flulike symptoms that can lead to fluid accumulation in the lungs and death. One of the pulmonary strains, the Sin Nombre virus (named for a Spanish massacre of Native Americans that occurred in the canyon where it was discovered), was the cause of a 1993 outbreak in the Four Corners area of the SW United States that killed 32 of 53 people known to have been infected. Sporadic occurrences of hantavirus pulmonary syndrome still occur in North America. Outbreaks of a hantavirus strain that apparently can be spread from person to person occurred in South America in 1996 and 1997. There is no vaccination for pulmonary hantavirus. Treatment includes respiratory and hemodynamic support; the antiviral drug ribavirin has been effective in some cases.


 

A genus in the family Bunyaviridae.

 
 

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Dictionary. The American Heritage® Dictionary of the English Language, Fourth Edition Copyright © 2007, 2000 by Houghton Mifflin Company. Updated in 2007. Published by Houghton Mifflin Company. All rights reserved.  Read more
Britannica Concise Encyclopedia. Britannica Concise Encyclopedia. © 2006 Encyclopædia Britannica, Inc. All rights reserved.  Read more
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Columbia Encyclopedia. The Columbia Electronic Encyclopedia, Sixth Edition Copyright © 2003, Columbia University Press. Licensed from Columbia University Press. All rights reserved. www.cc.columbia.edu/cu/cup/  Read more
Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved.  Read more

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