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Iron plays a critical role in the formation of hemoglobin.

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Because heme is low, the synthesis path continues to produce precursor molecules. Each porphyria corresponds with an enzyme defect and an amassing of associated precursor.

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Hemoglobin is the protein that, along with water, makes up a red blood cell. Hemoglobin is made from two substances, heme and globin. In order for hemoglobin synthesis to take place, two chains of globin must connect to one another. Without these chains, hemoglobin synthesis cannot happen.

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Heme + globin is Hemoglobin.

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