Hemosiderin is an iron-containing pigment derived in humans from
ferritin. It can be found in macrophages in small amounts
throughout a number of different tissues including the bone marrow,
liver and the spleen as a normal way to store iron. Under certain
conditions it can pathologically accumulate in excess amounts. In
hemosiderosis macrophages are hemosiderin-laden but without
associated damage to surrounding tissue. When there more extensive
accumulation occurs, it can lead to surrounding tissue damage,
scarring and organ dysfunction. This is called hemochromatosis.