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XinLi Zhu has written:

'Heparan sulphate proteoglycans in human kidney cortex'

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XinLi Zhu has written:

'Heparan sulphate proteoglycans in human kidney cortex'

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caused by a deficiency of the enzyme heparan sulfate sulfamidase, due to mutations in the SGSH gene on chromosome 17. Type IIIA is felt to be the most severe of the four types, in which symptoms appear and death occurs at an earlier age

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Polysaccharides are of two main types.

1. Homopolysaccharides

2. Heteropolysaccharides

Heteropolysaccharides are further classified as:

a) GlycosAminoGlycans (GAGs)

b) Glycoconjugates

c) Mucilages

Proteoglycan is a type of glycoconjugates whereas heparan sulfate, dermatan sulfate and hyaluronic acid are examples of GAGs.

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Dana Nohynek has written several works in the field of public health and vaccine research, focusing particularly on the epidemiology and prevention of infectious diseases. She has published numerous scientific articles and has been involved in various global health initiatives related to immunization.

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Definition

Acid mucopolysaccharides is a test that measures the amount of mucopolysaccharidesreleased into the urine over a 24-hour period. Mucopolysaccharides are long chains of sugar molecules found throughout the body, often in mucus and in fluid around the joints.

Alternative Names

AMP; Dermatan sulfate - urine; Urine heparan sulfate; Urine dermatan sulfate; Heparan sulfate - urine

How the test is performed

A 24-hour urine sample is needed.

  • On day 1, urinate into the toilet when you get up in the morning.
  • Afterwards, collect all urine in a special container for the next 24 hours. Keep it in the refrigerator or a cool place during the collection period.
  • On day 2, urinate into the container when you get up in the morning.
  • Cap the container. Label the container with your name, the date, the time of completion, and deliver it to the laboratory or your health care provider as soon as possible.
How to prepare for the test

There is no special preparation needed.

How the test will feel

The test involves only normal urination, and there is no discomfort.

Why the test is performed

This test is done to diagnose a rare group of genetic disorders called mucopolysaccharidoses, including Hurler syndrome.

This test is usually only done in infants who have a family history of one of these disorders.

Normal Values

Normal levels vary with age and from lab to lab.

What abnormal results mean

Abnormally high levels are a sign of mucopolysaccharidosis. Further tests are needed to determine the specific type of mucopolysaccharidosis.

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