Hepatosplenomegaly

Hepatosplenomegaly is the simultaneous enlargement of both the liver (hepatomegaly) and the spleen (splenomegaly). Hepatosplenomegaly can occur as the result of acute viral hepatitis, infectious mononucleosis or can be the sign of a serious and life threatening lysosomal storage disease.

Common causes

• Infection:
  • Acute viral hepatitis^[1][2]
  • Infectious mononucleosis^[2][1]
  • Cytomegalovirus^[2][1]
  • Rubella^[1]
  • Malaria^[1]
  • Leishmaniasis^[1]

• Haematological disease:
  • Myeloproliferative disease^[2][1]
  • Leukaemia^[2][1]
  • Lymphoma^[2][1]
  • Pernicious anaemia^[2]
  • Sickle cell anaemia^[2]
  • Thalassaemia^[2]
  • Myelofibrosis^[1]

• Chronic liver disease and portal hypertension:
  • Chronic active hepatitis^[2]

• Amyloidosis^[2]

• Acromegaly^[2]

• Systemic lupus erythematosus^[2]

References

External links

• National Niemann Pick Disease Foundation
• Hide and Seek Foundation For Lysosomal Disease Research
• 1516961800 at GPnotebook
• vii/h/HEPATOSPLENOMEGALY article at GE's Medcyclopaedia

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