(biochemistry) C5H9O3N An amino acid that is essentially limited to structural proteins of the collagen type.
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McGraw-Hill Science & Technology Dictionary:
hydroxyproline |
(biochemistry) C5H9O3N An amino acid that is essentially limited to structural proteins of the collagen type.
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Oxford Food & Nutrition Dictionary:
hydroxyproline |
Amino acid mainly in connective tissue proteins (collagen and elastin); incorporated into the protein as proline and then hydroxylated in a vitamin-C-dependent reaction. Peptides of hydroxyproline are excreted in the urine and the output is increased when collagen turnover is high, as in rapid growth or resorption of tissue.
Oxford Dictionary of Sports Science & Medicine:
hydroxyproline |
A chemical similar to an amino acid and found in connective tissue. An increase in urinary hydroxyproline is indicative of damage and breakdown of connective tissue.
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hydroxyproline |
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Oxford Dictionary of Biochemistry:
hydroxyproline |

| hydroxyphenylpyruvate reductase, hydroxymethylglutaryl-CoA synthase, hydroxymethylglutaryl-CoA reductase | |
| hydroxyproline-rich glycoproteins, hydroxyprolinemia, hydroxyurea |
Wikipedia on Answers.com:
Hydroxyproline |
| Hydroxyproline | |
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(2S,4R)-4-hydroxypyrrolidine- |
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| Identifiers | |
| CAS number | 51-35-4 |
| PubChem | 825 |
| ChemSpider | 236516 |
| UNII | RMB44WO89X |
| MeSH | Hydroxyproline |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C5H9NO3 |
| Molar mass | 131.13 g·mol−1 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
(2S,4R)-4-Hydroxyproline, or L-hydroxyproline (C5H9O3N), is a common non-proteinogenic amino acid, abbreviated as HYP, e.g., in Protein Data Bank.
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Contents
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In 1902, Hermann Emil Fischer isolated hydroxyproline from hydrolized gelatin. In 1905, Hermann Leuchs synthesized a racemic mixture of 4-hydroxyproline.[1]
Hydroxyproline differs from proline by the presence of a hydroxyl (OH) group attached to the gamma carbon atom.
Hydroxyproline is produced by hydroxylation of the amino acid proline by the enzyme prolyl hydroxylase following protein synthesis (as a post-translational modification). The enzyme catalysed reaction takes place in the lumen of the endoplasmic reticulum. Although it is not directly incorporated into proteins, hydroxyproline comprises roughly 4% of all amino acids found in animal tissue, more than seven amino acids which are directly incorporated.[2]
Hydroxyproline is a major component of the protein collagen[3]. Hydroxyproline and proline play key roles for collagen stability.[4] They permit the sharp twisting of the collagen helix.[5] In the canonical collagen Xaa-Yaa-Gly triad (where Xaa and Yaa are any amino acid), a proline occupying the Yaa position is hydroxylated to give a Xaa-Hyp-Gly sequence. This modification of the proline residue increases the stability of the collagen triple helix. It was initially proposed that the stabilization was due to water molecules forming a hydrogen bonding network linking the prolyl hydroxyl groups and the main-chain carbonyl groups.[6] It was subsequently shown that the increase in stability is primarily through stereoelectronic effects and that hydration of the hydroxyproline residues provides little or no additional stability.[7] In addition to collagen, the mammalian proteins elastin and argonaute 2 have collagen-like domains in which hydroxyproline is formed. Some snail poisons, conotoxins, contain hydroxyproline, but lack collagen-like sequences.[2]
Hydroxylation of proline has been shown to be involved in targeting Hypoxia-inducible factor (HIF) alpha subunit (HIF-1 alpha) for degradation by proteolysis. Under normoxia (normal oxygen conditions) EGLN1[1] protein hydroxylates the proline at the 564 position of HIF-1 alpha, which allows ubiquitylation by the von Hippel-Lindau tumor suppressor (pVHL) and subsequent targeting for proteasome degradation.[8]
Hydroxyproline is found in few proteins other than collagen. For this reason, hydroxyproline content has been used as an indicator to determine collagen and/or gelatin amount.
Hydroxyproline rich glycoproteins are also found in plant cell walls.[9]
Proline hydroxylation requires ascorbic acid (vitamin C). The most obvious, first effects (gingival and hair problems) of absence of ascorbic acid in humans come from the resulting defect in hydroxylation of proline residues of collagen, with reduced stability of the collagen molecule, causing scurvy.
Increased serum and urine levels of hydroxyproline have also been demonstrated in Paget's disease. [10]
Other hydroxyprolines also exist in nature, the most notable ones being 2,3-cis-, 3,4-trans-, and 3,4-dihydroxyproline, which occurs in diatom cell walls[11] and is postulated to have a role in silica deposition. Hydroxyproline is also found in the walls of oomycetes, fungus-like protists related to diatoms.[12] cis-4-hydroxyproline (2S, 4S) is found in the toxic cyclic peptides from Amanita mushrooms (e.g., alpha-amanitin and phalloidin)[13].
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