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Q: Does the Regulating hormones from the hypothalamus first enter into the hypophyseal portal system?

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yes

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first enter into the hypophyseal portal system

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1) Hepatic Portal Vein

2) Renal Portal System

3) Hypothalamic-Hypophyseal Portal System

not so sure about number 2 :P

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the Hypophyseal Portal System.

It carries blood directly from the hypothalmus to the adenohypohysis. It allows a small amount of hormone to be delivered directly to the target tissue without dilution.

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The hypophyseal portal veins.

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