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Indapamide

 
Dental Dictionary: indapamide

n

trade name: Lozol; drug class: diuretic, thiazide-like; action: acts on distal tubule by increasing excretion of water, sodium, chloride, potassium; uses: edema, hypertension.

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Drug Info: Indapamide
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Brand names: Lozol®

Chemical formula:



Indapamide tablets

What are indapamide tablets?

INDAPAMIDE (Lozol®) is a diuretic. Diuretics increase the amount of urine passed, which causes the body to lose water and salt. Indapamide helps to treat high blood pressure (hypertension). It is not a cure. It also reduces the swelling and water retention caused by various medical conditions, such as heart, liver, or kidney disease. Generic indapamide tablets are available.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
• diabetes
• gout
• kidney disease, small amounts of urine, or difficulty passing urine
• liver disease
• low blood levels of potassium, chloride, or sodium
• thyroid disease
• an unusual or allergic reaction to indapamide, sulfa drugs, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I take this medicine?

Take indapamide tablets by mouth. Follow the directions on the prescription label. Swallow the tablets with a drink of water. Take your doses at regular intervals. Do not take your medicine more often than directed. Remember that you will need to pass urine frequently after taking indapamide. Do not take your doses at a time of day that will cause you problems. Do not take at bedtime.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What drug(s) may interact with indapamide?

amiodarone
dofetilide
• heart medicines such as digoxin
lithium
• medicines for diabetes
• medicines for high blood pressure
• medicines that relax muscles for surgery
• medicine for colds and breathing difficulties
• monoamine oxidase inhibitors (Azilect®, Eldepryl®, Emsam®, Marplan®, Nardil®, Parnate®, Zelapar™)
• water pills

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What should I watch for while taking indapamide?

Visit your prescriber or health care professional for regular checks on your progress. Check your blood pressure regularly. Ask your prescriber or health care professional what your blood pressure should be, and when you should contact him or her. You must not get dehydrated, ask your prescriber or health care professional how much fluid you need to drink a day. Do not stop taking indapamide except on your prescriber's advice.

Watch your diet while you are taking indapamide. Ask your prescriber or health care professional about both potassium and sodium intake. Indapamide can make your body lose potassium and you may need an extra supply. Too high or too low potassium can cause problems. Some foods have a high potassium content such as bananas, coconuts, dates, figs, prunes, apricots, peaches, grapefruit juice, tomato juice, and orange juice.

You may get dizzy or lightheaded. Do not drive, use machinery, or do anything that needs mental alertness until you know how indapamide affects you. To reduce the risk of dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. Alcohol can make you lightheaded, dizzy and increase confusion. Avoid or limit intake of alcoholic drinks.

Indapamide may make your skin more sensitive to sun or ultraviolet light. Keep out of the sun, or wear protective clothing outdoors and use a sunscreen (at least SPF 15). Do not use sun lamps or sun tanning beds or booths.

If you are going to have surgery, tell your prescriber or health care professional that you are taking indapamide.

Indapamide can increase the amount of sugar in blood or urine. If you are a diabetic keep a close check on blood and urine sugar.

What side effects may I notice from taking indapamide?

Side effects that you should report to your prescriber or health care professional as soon as possible:
• blurred vision
• change in the amount or frequency of urination
• dry mouth
• increased thirst
• irregular heartbeat (palpitations)
• mood changes
• muscle cramps or spasm
• nausea, vomiting
• seizures (convulsions)
• skin rash, itching, or hives
• unusual tiredness or weakness
• yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• diarrhea
• difficulty sleeping
• dizziness or lightheadedness
• headache
• increased sensitivity to the sun
• loss of appetite
• sexual difficulties (impotence)
• stomach upset

Where can I keep my medicine?

Keep out of the reach of children in a container that small children cannot open.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.

Last updated: 7/1/2002

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

Medical Dictionary: in·dap·a·mide
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(ĭn-dăp'ə-mīd')
n.

A loop diuretic used to treat edema associated with congestive heart failure, hepatic cirrhosis, and renal disease.

WordNet: indapamide
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Note: click on a word meaning below to see its connections and related words.

The noun has one meaning:

Meaning #1: diuretic (trade name Lozal) used in the treatment of hypertension
  Synonym: Lozal


Wikipedia: Indapamide
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Indapamide
Systematic (IUPAC) name
4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)- 3-sulfamoyl-benzamide
Identifiers
CAS number 26807-65-8
ATC code C03BA11
PubChem 3702
DrugBank APRD01031
Chemical data
Formula C16H16ClN3O3S 
Mol. mass 365.835 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 71-79%
Metabolism Hepatic
Half life 14-18 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status

POM

Routes Oral tablet
 Yes check.svgY(what is this?)  (verify)

Indapamide is a non-thiazide sulphonamide diuretic drug marketed by Servier, generally used in the treatment of hypertension, as well as decompensated cardiac failure. The US trade name for indapamide is Lozol.[1] Indapamide is marketed as Natrilix outside of the US. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are also available.

It is described as a thiazide-like diuretic.[2]

Contents

Form and composition

Indapamide is available generically as 1.25 mg and 2.5 mg non-scored tablets.[3]

Indications

Hypertension and edema due to congestive heart failure. Indapamide has been proven in the HYVET trial to reduce stroke and all cause mortality when given with or without perindopril to people over the age of 80 for the treatment of hypertension.

Dosage and administration

The adult dosage is 1.25 to 5 mg by mouth once daily usually in the morning.

Contraindications

Indapamide is contraindicated in known hypersensitivity to sulfonamides, severe renal failure, hepatic encephalopathy or severe hepatic failure and hypokalemia (low blood potassium levels).

There is insufficient safety data to recommend indapamide use in pregnancy or breastfeeding.

Interactions

Caution is advised in the combination of indapamide with lithium and nonantiarrhythmic drugs causing wave burst arrhythmia (astemizole, bepridil, IV erythromycin, halofantrine, pentamidine, sultopride, terfenadine, vincamine).

Precautions

Monitoring of potassium and uric acid serum levels is recommended, especially in subjects with a predisposition or a sensitivity to hypokalemia and in patients with gout.

Adverse effects

Commonly reported adverse events are hypokalemia (low potassium levels), fatigue, orthostatic hypotension (blood pressure decrease on standing up) and allergic manifestations.

Overdosage

Symptoms of overdosage would be those associated with a diuretic effect: electrolyte disturbances, hypotension, and muscular weakness. Treatment should be symptomatic, directed at correcting the electrolyte abnormalities.

References


 
 
Learn More
Indapamide tablets
Antihypertensive Drugs: Precautions
Antihypertensive Drugs (surgical term)

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Copyrights:

Dental Dictionary. Mosby's Dental Dictionary. Copyright © 2004 by Elsevier, Inc. All rights reserved.  Read more
Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved.  Read more
Medical Dictionary. The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company Read more
WordNet. WordNet 1.7.1 Copyright © 2001 by Princeton University. All rights reserved.  Read more
Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Indapamide" Read more