n
trade name: Lozol; drug class: diuretic, thiazide-like; action: acts on distal tubule by increasing excretion of water, sodium, chloride, potassium; uses: edema, hypertension.
| Dental Dictionary: indapamide |
trade name: Lozol; drug class: diuretic, thiazide-like; action: acts on distal tubule by increasing excretion of water, sodium, chloride, potassium; uses: edema, hypertension.
| 5min Related Video: Indapamide |
| Drug Info: Indapamide |
Brand names: Lozol®
Chemical formula:

Indapamide tablets
What are indapamide tablets?
INDAPAMIDE (Lozol®) is a diuretic. Diuretics increase the amount of urine passed, which causes the body to lose water and salt. Indapamide helps to treat high blood pressure (hypertension). It is not a cure. It also reduces the swelling and water retention caused by various medical conditions, such as heart, liver, or kidney disease. Generic indapamide tablets are available.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
diabetes
gout
kidney disease, small amounts of urine, or difficulty passing urine
liver disease
low blood levels of potassium, chloride, or sodium
thyroid disease
an unusual or allergic reaction to indapamide, sulfa drugs, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding
How should I take this medicine?
Take indapamide tablets by mouth. Follow the directions on the prescription label. Swallow the tablets with a drink of water. Take your doses at regular intervals. Do not take your medicine more often than directed. Remember that you will need to pass urine frequently after taking indapamide. Do not take your doses at a time of day that will cause you problems. Do not take at bedtime.
Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.What drug(s) may interact with indapamide?
amiodarone
dofetilide
heart medicines such as digoxin
lithium
medicines for diabetes
medicines for high blood pressure
medicines that relax muscles for surgery
medicine for colds and breathing difficulties
monoamine oxidase inhibitors (Azilect®, Eldepryl®, Emsam®, Marplan®, Nardil®, Parnate®, Zelapar)
water pills
Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.
What should I watch for while taking indapamide?
Visit your prescriber or health care professional for regular checks on your progress. Check your blood pressure regularly. Ask your prescriber or health care professional what your blood pressure should be, and when you should contact him or her. You must not get dehydrated, ask your prescriber or health care professional how much fluid you need to drink a day. Do not stop taking indapamide except on your prescriber's advice.
Watch your diet while you are taking indapamide. Ask your prescriber or health care professional about both potassium and sodium intake. Indapamide can make your body lose potassium and you may need an extra supply. Too high or too low potassium can cause problems. Some foods have a high potassium content such as bananas, coconuts, dates, figs, prunes, apricots, peaches, grapefruit juice, tomato juice, and orange juice.
You may get dizzy or lightheaded. Do not drive, use machinery, or do anything that needs mental alertness until you know how indapamide affects you. To reduce the risk of dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. Alcohol can make you lightheaded, dizzy and increase confusion. Avoid or limit intake of alcoholic drinks.
Indapamide may make your skin more sensitive to sun or ultraviolet light. Keep out of the sun, or wear protective clothing outdoors and use a sunscreen (at least SPF 15). Do not use sun lamps or sun tanning beds or booths.
If you are going to have surgery, tell your prescriber or health care professional that you are taking indapamide.
Indapamide can increase the amount of sugar in blood or urine. If you are a diabetic keep a close check on blood and urine sugar.
What side effects may I notice from taking indapamide?
Side effects that you should report to your prescriber or health care professional as soon as possible:
blurred vision
change in the amount or frequency of urination
dry mouth
increased thirst
irregular heartbeat (palpitations)
mood changes
muscle cramps or spasm
nausea, vomiting
seizures (convulsions)
skin rash, itching, or hives
unusual tiredness or weakness
yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
diarrhea
difficulty sleeping
dizziness or lightheadedness
headache
increased sensitivity to the sun
loss of appetite
sexual difficulties (impotence)
stomach upset
Where can I keep my medicine?
Keep out of the reach of children in a container that small children cannot open.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.
Last updated: 7/1/2002
Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.
| Medical Dictionary: in·dap·a·mide |
A loop diuretic used to treat edema associated with congestive heart failure, hepatic cirrhosis, and renal disease.
| WordNet: indapamide |
The noun has one meaning:
Meaning #1:
diuretic (trade name Lozal) used in the treatment of hypertension
Synonym: Lozal
| Wikipedia: Indapamide |
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Indapamide
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| Systematic (IUPAC) name | |
| 4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)- 3-sulfamoyl-benzamide | |
| Identifiers | |
| CAS number | 26807-65-8 |
| ATC code | C03BA11 |
| PubChem | 3702 |
| DrugBank | APRD01031 |
| Chemical data | |
| Formula | C16H16ClN3O3S |
| Mol. mass | 365.835 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | 71-79% |
| Metabolism | Hepatic |
| Half life | 14-18 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
POM |
| Routes | Oral tablet |
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Indapamide is a non-thiazide sulphonamide diuretic drug marketed by Servier, generally used in the treatment of hypertension, as well as decompensated cardiac failure. The US trade name for indapamide is Lozol.[1] Indapamide is marketed as Natrilix outside of the US. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are also available.
It is described as a thiazide-like diuretic.[2]
Contents |
Indapamide is available generically as 1.25 mg and 2.5 mg non-scored tablets.[3]
Hypertension and edema due to congestive heart failure. Indapamide has been proven in the HYVET trial to reduce stroke and all cause mortality when given with or without perindopril to people over the age of 80 for the treatment of hypertension.
The adult dosage is 1.25 to 5 mg by mouth once daily usually in the morning.
Indapamide is contraindicated in known hypersensitivity to sulfonamides, severe renal failure, hepatic encephalopathy or severe hepatic failure and hypokalemia (low blood potassium levels).
There is insufficient safety data to recommend indapamide use in pregnancy or breastfeeding.
Caution is advised in the combination of indapamide with lithium and nonantiarrhythmic drugs causing wave burst arrhythmia (astemizole, bepridil, IV erythromycin, halofantrine, pentamidine, sultopride, terfenadine, vincamine).
Monitoring of potassium and uric acid serum levels is recommended, especially in subjects with a predisposition or a sensitivity to hypokalemia and in patients with gout.
Commonly reported adverse events are hypokalemia (low potassium levels), fatigue, orthostatic hypotension (blood pressure decrease on standing up) and allergic manifestations.
Symptoms of overdosage would be those associated with a diuretic effect: electrolyte disturbances, hypotension, and muscular weakness. Treatment should be symptomatic, directed at correcting the electrolyte abnormalities.
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This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
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