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pyrophosphatase (inorganic) 1
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| Identifiers | |
| Symbol | PPA1 |
| Alt. Symbols | PP |
| Entrez | 5464 |
| HUGO | 9226 |
| OMIM | 179030 |
| RefSeq | NM_021129 |
| UniProt | Q15181 |
| Other data | |
| EC number | 3.6.1.1 |
| Locus | Chr. 10 q11.1-q24 |
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pyrophosphatase (inorganic) 2
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| Identifiers | |
| Symbol | PPA2 |
| Entrez | 27068 |
| HUGO | 28883 |
| OMIM | 609988 |
| RefSeq | NM_176869 |
| UniProt | Q9H2U2 |
| Other data | |
| Locus | Chr. 4 q25 |
Pyrophosphatase (or inorganic pyrophosphatase) is an enzyme that converts one molecule of pyrophosphate to two phosphate ions. This highly exergonic reaction (about −34KJ change in free energy) can be coupled to unfavorable biochemical transformations in order to drive these transformations to completion, as in lipid synthesis and other biochemical transformations.
Thermostable pyrophosphatase has been isolated from the extremophile Thermococcus litoralis.
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