"Designer breed" is just a fancy name for an intentionally mixed
bred dog. They're still considered mutts by kennel clubs and do not
breed true. For example, if you breed a cock-a-poo to a cock-a-poo
you don't necessarily get something that looks like a cock-a-poo.
It might look more like a Cocker Spaniel or Miniature Poodle.
You can breed just about any breed of dog to another, especially
if they are of similar size. If one parent is significantly larger
than the other it may actually kill the mother if she is the
smaller of the two.
Mixed breeds occur enough by accident without being
intentionally bred by people looking for an easy income. Most
designer breed dogs are created in puppy mills. So consider
rescuing first. Save money and save a life. A mixed breed dog
doesn't have to cost thousands of dollars just for a cute name.
Cute names are abundant and free.