interleukin-8

Interleukin 8
Image source: PDB rendering based on 1IL8.
Available structures: 1icw, 1ikl, 1ikm, 1il8, 1ilp, 1ilq, 1qe6, 2il8, 3il8
Identifiers
Symbol(s)	IL8; 3-10C; AMCF-I; CXCL8; GCP-1; GCP1; K60; LECT; LUCT; LYNAP; MDNCF; MONAP; NAF; NAP-1; NAP1; SCYB8; TSG-1; b-ENAP
Gene Ontology Molecular Function: • interleukin-8 receptor binding • protein binding • chemokine activity Cellular Component: • extracellular region • extracellular space Biological Process: • angiogenesis • cell motility • chemotaxis • inflammatory response • immune response • cell cycle arrest • G-protein coupled receptor protein signaling pathway • intracellular signaling cascade • cell-cell signaling • negative regulation of cell proliferation • calcium-mediated signaling • regulation of cell adhesion • neutrophil chemotaxis • neutrophil activation • regulation of retroviral genome replication • induction of positive chemotaxis
Expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	3576	na
Ensembl	ENSG00000169429	na
Uniprot	P10145	na
Refseq	NM_000584 (mRNA) NP_000575 (protein)	na (mRNA) na (protein)
Location	Chr 4: 74.83 - 74.83 Mb	na

Interleukin-8 (IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies^[1][2].

Toll-like receptors are the receptors of the innate immune system. These receptors recognize antigen patterns (like LPS in gram negative bacteria). Through a chain of biochemical reactions IL-8 is secreted and is a important mediator of the immune reaction in the innate immune system response.

The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q.^[3]

It is also secreted in urinary tract infections.

Function

IL-8 can be secreted by any cells with toll-like receptors which are involved in the innate immune response. IL-8's primary function is to recruit neutrophils to phagocytose the antigen which trigger the antigen pattern toll-like receptors.

When first encountering an antigen, the primary cells to encounter it are the macrophages who phagocytose the particle. Upon processing, they release chemokines to signal other immune cells to come in to the site of inflammation. IL-8 is one such chemokine. It serves as a chemical signal that attracts neutrophils at the site of inflammation, and therefore is also known as Neutrophil Chemotactic Factor.

Clinical significance

If a pregnant mother has high levels of interleukin-8, she has a higher risk of inducing schizophrenia in her offspring.^[4] High levels of Interleukin 8 have been shown to reduce the chance of good treatment responses to antipsychotic medication in schizophrenia.^[5]

Interleukin-8 is often associated with inflammation.

Nomenclature

IL-8 was renamed CXCL8 by the Chemokine Nomenclature Subcommittee of the Nomenclature Committee of the International Union of Immunological Societies, although its approved gene symbol remains IL8.

References

Further reading

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