Share on Facebook Share on Twitter Email
Answers.com

Ipratropium

 
Drug Info: Ipratropium

Brand names: Atrovent®Atrovent® HFA

Chemical formula:



Ipratropium Bromide Nebulizer solution

What is this medicine?

IPRATROPIUM (i pra TROE pee um) is a bronchodilator. It helps open up the airways in your lungs to make it easier to breathe. This medicine is used to prevent bronchospasms of Chronic Obstructive Pulmonary Disease. Do not use this medicine alone for an acute attack of bronchospasm.
 
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of the following conditions:
•bladder problems or difficulty passing urine
•glaucoma
•heart disease or irregular heartbeat
•prostate trouble
•an unusual or allergic reaction to ipratropium, atropine, bromides, soya protein, peanut oil, soybeans or peanuts, other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding

How should I use this medicine?

This medicine is used in a nebulizer. Nebulizers make a liquid into an aerosol that you breathe in through your mouth or your mouth and nose into your lungs. You will be taught how to use your nebulizer. Follow the directions on your prescription label. Do not use more often than directed. Do not stop taking except on your doctor's advice.

A patient information sheet for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What may interact with this medicine?

Ask your health care professional before you mix any medicines in the same dose of your nebulizer.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor for regular checks on your progress. Tell your doctor or health care professional if your symptoms do not improve. Do not use extra medicine. If your breathing gets worse or if you need short acting inhalers more often, call your doctor right away.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
•allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
•difficulty breathing or wheezing that increases or does not go away
•dizziness
•eye pain
•fast or irregular heartbeat
•infection or fever

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•blurred vision
•cough
•dry mouth
•headache
•nausea or constipation
•trouble passing urine

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Keep the vials in the carton until you are ready to use. Throw away any unused medicine after the expiration date.

Last updated: 7/1/2002

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

Search unanswered questions...
Enter a question here...
Search: All sources Community Q&A Reference topics
Medical Dictionary: ip·ra·tro·pi·um
Top
(ĭp'rə-trō'pē-əm)
n.

A synthetic compound, chemically related to atropine, that is used as an inhalant in the treatment of bronchospasm.

Veterinary Dictionary: ipratropium
Top

A synthetic anticholinergic used as a bronchodilator; similar to atropine but with fewer side-effects.

Wikipedia: Ipratropium
Top
Ipratropium
Systematic (IUPAC) name
[8-methyl-8-(1-methylethyl)- 8-azoniabicyclo[3.2.1] oct-3-yl] 3-hydroxy-2-phenyl-propanoate
Identifiers
CAS number 60205-81-4
ATC code R01AX03 R03BB01
PubChem 43232
DrugBank APRD00537
Chemical data
Formula C20H30NO3 
Mol. mass 332.457 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Protein binding 0 to 9% in vitro
Metabolism Hepatic
Half life 2 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

B(US)

Legal status

POM(UK)

Routes Inhalation
 Yes check.svgY(what is this?)  (verify)

Ipratropium (as ipratropium bromide, trade name Atrovent and Apovent[1]) is an anticholinergic drug.[2]

Contents

Uses

It is administered by inhalation for the treatment of obstructive lung diseases.

Ipratropium is also combined with albuterol (salbutamol) (trade names Combivent and Duoneb, in Italy known as Breva) for the management of chronic obstructive pulmonary disease (COPD) and asthma.

Ipratropium is also combined with fenoterol (trade names Duovent and Berodual N) for the management of asthma.

Ipratropium can reduce rhinorrhea but will not help nasal congestion.

Pharmacology

It blocks muscarinic cholinergic receptors, without specificity for subtypes, resulting in a decrease in the formation of cyclic guanosine monophosphate (cGMP). Most likely due to actions of cGMP on intracellular calcium, this results in decreased contractility of smooth muscle in the lung, inhibiting bronchoconstriction and mucus secretion. It is a non-selective muscarinic antagonist, and does not diffuse into the blood, which prevents systemic side-effects. Ipratropium is a derivative of atropine[3] but is a quaternary amine and therefore does not cross the blood-brain barrier, which prevents central side-effects (anticholinergic syndrome). Ipratropium is considered a short-acting bronchodilator.[4][5]

Side effects

If ipratropium is inhaled, side-effects resembling those of other anticholinergics are minimal. However, dry mouth and sedation have been reported. Also effects such as skin flushing, tachycardia, acute angle ocular dislocure, nausea, palpitations and headache have been observed.

References

  1. ^ http://drugs-about.com/drugs/apovent.html
  2. ^ Baigelman W, Chodosh S (March 1977). "Bronchodilator action of the anticholinergic drug, ipratropium bromide (Sch 1000), as an aerosol in chronic bronchitis and asthma". Chest 71 (3): 324–8. PMID 138578. http://www.chestjournal.org/cgi/pmidlookup?view=long&pmid=138578. 
  3. ^ Yamatake Y, Sasagawa S, Yanaura S, Okamiya Y (1977). "[Antiallergic asthma effect of ipratropium bromide (Sch 1000) in dogs (author's transl)]" (in Japanese). Nippon Yakurigaku Zasshi 73 (7): 785–91. PMID 145994. 
  4. ^ Kerstjens HA, Bantje TA, Luursema PB, et al. (2007). "Effects of short-acting bronchodilators added to maintenance tiotropium therapy". Chest 132 (5): 1493–9. doi:10.1378/chest.06-3059. PMID 17890476. 
  5. ^ Knott L (November 20, 2007). "Antimuscarinic Bronchodilators". PatientUK. EMIS. http://www.patient.co.uk/showdoc/40025112/. Retrieved 2008-06-16. 

 
 

 

Copyrights:

Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved.  Read more
Medical Dictionary. The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company Read more
Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved.  Read more
Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Ipratropium" Read more