An ISO image is an archive file (also known as a disc image) of an optical disc in a format defined by the International Organization for Standardization (ISO).

ISO file can not be played on a media player unless you use some other software mount the disc and then run the content (if possible) just like a CD.

ISO 32000 standardizes the PDF (Portable Document Format)

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You can not edit games on a xbox 360 with a ISO file format.

Even if you did edit the ISO file, you will need to mod your xbox to play a ISO file.

The format .uif is for Magic ISO Universal Image Format. It can open DVD image files and convert bin to iso and back. The uif file is a compression image file format for backing up CD's or DVD's.