Dental Dictionary:
isosorbide mononitrate |
trade name: ISMO; drug class: antianginal, organic nitrate; action: decreases preload/afterload, which is responsible for decreasing left ventricular end-diastolic pressure, systemic vascular resistance; arterial and venous dilation; use: prevention of angina pectoris caused by coronary artery disease.
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Isosorbide mononitrate |
Drug Info:
Isosorbide Mononitrate |
Brand names: Imdur®, Ismo®, Monoket®
Chemical formula:
Isosorbide Mononitrate Oral tablet, extended-release
What is this medicine?
ISOSORBIDE MONONITRATE is a vasodilator. It relaxes blood vessels, increasing the blood and oxygen supply to your heart. This medicine is used to prevent chest pain caused by angina. It will not help to stop an episode of chest pain.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
• previous heart attack or heart failure
• an unusual or allergic reaction to isosorbide mononitrate, nitrates, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding
How should I use this medicine?
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not crush, cut, or chew. Take this medicine on an empty stomach, at least 30 minutes before or 2 hours after food. Do not take with food. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking this medicine except on the advice of your doctor or health care professional.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What may interact with this medicine?
Do not take this medicine with any of the following medications:
• medicines used to treat erectile dysfunction (ED) like sildenafil, tadalafil, and vardenafil
This medicine may also interact with the following medications:
• medicines for high blood pressure
• other medicines for angina or heart failure
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Check your heart rate and blood pressure regularly while you are taking this medicine. Ask your doctor or health care professional what your heart rate and blood pressure should be and when you should contact him or her. Tell your doctor or health care professional if you feel your medicine is no longer working.
You may get dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. To reduce the risk of dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. Alcohol can make you more dizzy, and increase flushing and rapid heartbeats. Avoid alcoholic drinks.
Do not treat yourself for coughs, colds, or pain while you are taking this medicine without asking your doctor or health care professional for advice. Some ingredients may increase your blood pressure.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
• bluish discoloration of lips, fingernails, or palms of hands
• irregular heartbeat, palpitations
• low blood pressure
• nausea, vomiting
• persistent headache
• unusually weak or tired
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
• flushing of the face or neck
• rash
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medicine?
Keep out of the reach of children.
Store between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.
Last updated: 7/1/2002
Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.
Wikipedia:
Isosorbide mononitrate |
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This article needs additional citations for verification. Please help improve this article by adding reliable references. Unsourced material may be challenged and removed. (July 2007) |
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|
| Systematic (IUPAC) name | |
|---|---|
| 8-nitrooxy-2,6-dioxabicyclo[3.3.0]octan-4-ol | |
| Identifiers | |
| CAS number | 16051-77-7 |
| ATC code | C01DA14 |
| PubChem | 27661 |
| DrugBank | APRD00528 |
| Chemical data | |
| Formula | C6H9NO6 |
| Mol. mass | 191.139 g/mol |
| Pharmacokinetic data | |
| Bioavailability | >95% |
| Protein binding | <5% |
| Metabolism | Hepatic |
| Half life | 5 hours |
| Excretion | Renal: 93% |
| Therapeutic considerations | |
| Pregnancy cat. |
C (USA) |
| Legal status | |
| Routes | Oral |
 (what is this?) (verify) |
|
Isosorbide mononitrate is a drug used principally in the treatment of angina pectoris[1] and acts by dilating the blood vessels so as to reduce the blood pressure. It is sold by AstraZeneca under the trade name Imdur, and marketed in the UK under the trade names: Monosorb, Chemydur. In india this drug is available under the brand names of Sorbitrate, Monotrate, Solotrate, and Monit.
Contents |
Isosorbide mononitrate is used for the prophylactic treatment of angina pectoris; that is, it is taken in order to prevent or at least reduce the occurrence of angina. Research on Isosorbide mononitrate as a cervical ripener to reduce time at hospital to birth is supportive.[2]
The adverse reactions which follow have been reported in studies with isosorbide mononitrate:
Very common: Headache predominates (up to 30%) necessitating withdrawal of 2 to 3 % of patients, but the incidence reduces rapidly as treatment continues .
Common: Tiredness, sleep disturbances (6%) and gastrointestinal disturbances (6%) have been reported during clinical trials with isosorbide mononitrate modified release tablets, but at a frequency no greater than for placebo. Hypotension (4 to 5%), poor appetite (2.5%), nausea (1%).
Adverse effects associated with the clinical use of the drug are as expected with all nitrate preparations. They occur mainly in the early stages of treatment.
Hypotension (4%) with symptoms such as dizziness and nausea (1%) have been reported. These symptoms generally disappear during long-term treatment.
Other reactions that have been reported with isosorbide mononitrate modified release tablets include tachycardia, vomiting, diarrhoea, vertigo and heartburn.
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This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
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Copyrights:
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 | Dental Dictionary. Mosby's Dental Dictionary. Copyright © 2004 by Elsevier, Inc. All rights reserved. Read more |
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| Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved. Read more |
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| Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Isosorbide mononitrate". Read more |
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