Jonas Salk

Jonas Salk
Salk in 1955 at the University of Pittsburgh
Born	October 28, 1914(1914-10-28) New York City, New York, United States
Died	June 23, 1995 (age 80) La Jolla, California, United States
Residence	USA
Nationality	American
Ethnicity	Russian-Jewish
Fields	Medical research, virology and epidemiology
Institutions	University of Pittsburgh
Alma mater	City College of New York New York University
Doctoral advisor	Thomas Francis, Jr.
Known for	First polio vaccine
Notable awards	Lasker Award (1956)

Jonas Salk (October 28, 1914 – June 23, 1995) was an American medical researcher and virologist, best known for his discovery and development of the first safe and effective polio vaccine. He was born in New York City, where his parents were Russian-Jewish immigrants. Although they themselves lacked formal education, they were determined to see their children succeed. While attending medical school at New York University, he stood out from his peers not just because of his academic prowess, but because he chose to do medical research instead of becoming a physician.

Until 1955, when the Salk vaccine was introduced, polio was considered the most frightening public health problem of the postwar United States. Annual epidemics were increasingly devastating, and by 1952 it was killing more juveniles than any other communicable disease, with over 300,000 cases and 58,000 deaths, most of them children, reported that year. The "public reaction was to a plague," said historian William O'Neill. "Citizens of urban areas were to be terrified every summer when this frightful visitor returned." As a result, scientists were in a frantic race to find a cure. US President Franklin D. Roosevelt was the world's most recognized victim of the disease and founded the institute to fund and create a vaccine.

In 1947, Salk accepted an appointment to the University of Pittsburgh School of Medicine. While working there, with the National Foundation for Infantile Paralysis, Salk saw an opportunity to develop a vaccine against polio, and devoted himself to this work for the next eight years. The field tests Salk set up were, according to O'Neill, "the most elaborate program of its kind in history, involving 20,000 physicians and public health officers, 64,000 school personnel, and 220,000 volunteers." When news of the discovery was made public on April 12, 1955, Salk was hailed as a "miracle worker," and the day "almost became a national holiday." He further endeared himself to the public by refusing to patent the vaccine for his personal profit, as he wished to see it disseminated as quickly and as widely as possible and patenting would have hampered this. When asked who owned the patent, Salk replied: "There is no patent. Could you patent the sun?"

In 1963, he founded the Salk Institute for Biological Studies in La Jolla, which is today a center for medical and scientific research. He continued to conduct research and publish books, including Man Unfolding (1972), The Survival of the Wisest (1973), World Population and Human Values: A New Reality (1981), and Anatomy of Reality (1983). Dr. Salk's last years were spent searching for a vaccine against HIV.

Early life

Jonas Salk was born in New York City on October 28, 1914. His parents, Daniel and Dora Salk were Russian-Jewish immigrants. According to historian David Oshinsky, Salk grew up in the "Jewish immigrant culture" of New York. He had two younger brothers, Lee and Herman, and an uncle, Bruno Salk. The family lived in East Harlem, later moving to the Bronx and eventually settled in Queens.

His father, Daniel, unable to complete grade school in Russia, eventually emigrated to the US where he worked in New York's garment district. Lee Salk, in his autobiography, would write of him: "He was something of a Willy Loman character from Death of a Salesman, beaten down in business but still believing that success would soon be his." Because of his long hours at work he had to leave most of the child-rearing duties to his wife.^[1]:10

Jonas's mother was also mostly uneducated and likewise had emigrated to the US. According to Jonas, "She wanted to be sure that we all were going to advance in the world. Therefore we were encouraged in our studies and overly protected." She was best remembered for "pushing her three sons relentlessly to excel," writes Oshinsky.^[2]:95

In later years his brother Herman became a veterinarian and Lee became a clinical psychologist.

Education

High school

When he was 12, Salk entered Townsend Harris High School, a public school for intellectually gifted students. Named after the founder of City College of New York (CCNY), it was, wrote Oshinsky, "a launching pad for the talented sons of immigrant parents who lacked the money - and pedigree - to attend a top private school." In high school "he was known as a perfectionist... who read everything he could lay his hands on," according to one of his fellow students.^[3] Students were generally forced to cram a four-year curriculum into just three. As a result, most dropped out or flunked out, despite the school's motto "study, study, study." Of the students who graduated, however, most would have the grades to enroll in CCNY, noted for being a highly competitive college.^[2]:96

College

Jonas enrolled in City College of New York at the height of the Great Depression where he earned a Bachelor of Science degree. Oshinsky writes that "for working-class immigrant families, City College represented the apex of public higher education. Getting in was tough but tuition was free. Competition was intense, but the rules were fairly applied. No one got an advantage based on an accident of birth."^[2]

At his mother's urging, he put aside aspirations of becoming a lawyer, and instead concentrated on classes necessary for admission to medical school. However, according to Oshinsky, the facilities at City College were "barely second rate." There were no research laboratories. The library was inadequate. The faculty contained few noted scholars. "What made the place special," he writes, "was the student body that had fought so hard to get there . . . driven by their parents. . . From these ranks, of the 1930s and 1940s, emerged a wealth of intellectual talent, including more Nobel Prize winners - eight - and PhD recipients than any other public college except the University of California at Berkeley." Salk entered City College at the age of 15, a "common age for a freshman who had skipped multiple grades along the way."^[2]:98

As a child, Salk did not show any interest in medicine or science in general. He says in an interview with the Academy of Achievement^[4] "As a child I was not interested in science. I was merely interested in things human, the human side of nature, if you like, and I continue to be interested in that. That's what motivates me. And in a way, it's the human dimension that has intrigued me."

Medical school

According to Oshinsky, NYU based its modest reputation on famous alumni, such as Walter Reed, who helped conquer yellow fever. Tuition was "comparatively low, better still, it did not discriminate against Jews, ... while most of the surrounding medical schools - Cornell, Columbia, University of Pennsylvania, and Yale - had rigid quotas in place." Yale, for example, accepted 76 applicants, in 1935, out of a pool of 501. Although 200 of the applicants were Jewish, only five got in.^[2]:98

During his years at the Medical School of New York University he stood out from his peers, according to Bookchin, "not just because of his continued academic prowess -- he was Alpha Omega Alpha, the Phi Beta Kappa of medical education -- but because he had decided he did not want to practice medicine." Instead, he became absorbed in research, even taking a year off to study biochemistry. He later focused more of his studies on bacteriology which had replaced medicine as his primary interest. His said his desire was to help humankind in general rather than single patients.^[3] And as Oshinsky writes, "it was the laboratory work, in particular, that gave new direction to his life.^[2]

Post-graduate research

During his senior year in medical school he chose a two-month elective to work in the laboratory of Dr. Thomas Francis. Francis had recently joined the faculty of the medical school after working for the Rockefeller Foundation, where he had discovered the Type B influenza virus. According to Bookchin, "the two month stint in Francis's lab was Salk's first introduction to the world of virology - and he was hooked."^[3]:25

After graduating from medical school he began his residency at New York's Mount Sinai Hospital, where he again worked in Francis's laboratory. Few hospitals in Manhattan had the status of Mount Sinai, particularly among the city's Jews. Oshinsky interviewed a friend of Salk's, who said, "to intern there was like playing ball for the New York Yankees ... only the top men from the nation's medical schools dared apply. Out of 250 who sought the opportunity, only a dozen were chosen."^[2]

According to Oshinsky, "Salk quickly made his mark." Although focused mainly on research, "he showed tremendous skills as a clinician and a surgeon." But it was "his leadership as president of the house staff of interns and residents at Mount Sinai that best defined him to his peers." The key issue for many of them in 1939, for example, was not the fate of the hospital, but rather the future of Europe after Nazi Germany's invasion of Poland. In one instance, "several interns responded by wearing badges to signify support for the Allies," but the hospital's director told them to remove them lest they upset some of the patients.

The interns then took the matter to Salk, where he said that "everyone should wear the badge as an act of solidarity." One intern recalled, "Jonas was a very staunch guy. He never took a backward step on that issue or any other issue of principle between us and the hospital." The hospital administrators backed off and there was no further interference from the director.^[2]

Research career

At the end of his residency, Salk began applying for permanent research positions. But he discovered that many of the jobs he desired were closed to him due to Jewish quotas, which, according to Bookchin, "prevailed in so much of the medical research establishment." Nor could he apply at Mount Sinai as their policy prevented hiring their own interns. As a last resort, he contacted Dr. Francis for help. But Francis had left NYU a year earlier after accepting an offer to direct the University of Michigan's School of Public Health.

Salk in the Virus Research Lab at the University of Pittsburgh

However, "Francis did not let him down," writes Bookchin. "He secured extra grant money and offered Salk a job" working on an army-commissioned project in Michigan to develop an influenza vaccine. He and Francis eventually perfected a vaccine that was soon widely used at army bases, where "Salk had been responsible for discovering and isolating one of the flu strains that was included in the final vaccine.^[3]:26

By 1947, Salk decided to find an institution where he could direct his own laboratory. After three institutions turned him down, he received an offer from William McEllroy, the dean of the University of Pittsburgh School of Medicine, which included a promise that he would run his own lab. He accepted, and in the fall of that year left Michigan and relocated to Pennsylvania. But the promise was not quite what he expected. After Salk arrived at Pittsburgh, "he discovered that he had been relegated to cramped, unequipped quarters in the basement of the old Municipal Hospital," writes Bookchin. As time went on, however, he began securing grants from the Mellon family and was able to build a working virology laboratory, where he continued his research on flu vaccines.^[3]

He was later approached by the director of research at the National Foundation for Infantile Paralysis and asked if he would like to participate on the foundation's polio project, which had earlier been established by President Franklin D. Roosevelt, a victim of polio himself. He quickly accepted the offer saying he "would be happy to work on this important project."^[3]

Joining fight against polio

The worst disease of the postwar era

Polio was a medical oddity that baffled researchers for years. It was first recorded in 1835 and grew steadily more prevalent. It took a long time to learn that the virus was transmitted by fecal matter and secretions of the nose and throat. It entered the victim orally, established itself in the intestines, and then traveled to the brain or spinal cord.^[5]

There were many other famous polio victims, most of whom were able to overcome their disabilities, while others were less fortunate: Itzhak Perlman, one of the world's finest violinists, was permanently disabled at age four, and still plays sitting down; actor Donald Sutherland; recently-deceased writer Arthur C. Clarke; actress Mia Farrow; singer-musician Neil Young; actor Alan Alda; musician David Sanborn; singer Dinah Shore; singer Joni Mitchell; former Supreme Court Justice William O. Douglas; director Francis Ford Coppola; nuclear physicist J. Robert Oppenheimer; actor Lionel Barrymore;^[6] and Congressman James H. Scheuer.^[7]

According to American historian William O'Neill, "Paralytic poliomyelitis [its generic name] was, if not the most serious, easily the most frightening public health problem of the postwar era." He noted that the epidemics kept getting worse and its victims were usually children. By 1952 it was killing more of them than any other communicable disease. Of the twenty states that reported the disease back in 1916, there were 27,363 cases. New York alone had 9,023 cases of which 2,448 (28%) resulted in death, and a larger number in paralysis.^[5]:136 However, polio did not gain national attention until 1921, when Franklin D. Roosevelt, former vice presidential candidate and soon to be governor of New York, came down with the disease.^[8] At the age of 39, Roosevelt was left with severe paralysis from the disease and spent most of his presidency in a wheelchair.

Subsequently, as more states began recording instances of the disease, the numbers of victims grew larger: According to historian James Olson, "during the 1950s, polio reached epidemic proportions. More than 150,000 cases were reported in 1950, and that number jumped to nearly 300,000 in 1952," with 58,000 deaths. In some parts of the country, concern assumed almost the dimensions of panic. Olson adds that "parents kept children home from school, avoided parks and swimming pools, and played only in small groups with the closest of friends." Cases usually increased during the summer when children were home from school. "The public reaction was to a plague," noted O'Neill. "Citizens of urban areas were to be terrified every summer when this frightful visitor returned."^[5] As a result, Olson points out, "scientists were in a frantic race to find a cure."^[8]

The fight begins

Oshinsky writes that as "headlines screamed, 'Polio Scourge,' 'Polio Panic,' and 'Polio's Deadly Path,'" parents "faced a dilemma" and a feeling of personal helplessness in the midst of an "apparently runaway epidemic." Their "postwar culture was being turned upside down" as polio became the "crack in the fantasy" of a suburban home "bursting with children." Parents began to see that there would be an alternative, however: "Since worry did no good and quarantine seemed fruitless, parents might best protect their children by helping others to discover a vaccine against polio, and, perhaps, even a cure." The public soon realized that this kind of research demanded "big money" and an "army of devoted volunteers,"^[2]:85-87 but Salk was determined to make it over this barrier.

The fight against polio did not really get under way until 1938 when the National Foundation for Infantile Paralysis was born. Basil O'Connor, the former law partner of President Roosevelt, the US' most famous polio victim, headed it. That same year, the first March of Dimes fundraising program was set up, with radio networks offering free 30-second slots for promotion. Listeners were asked to send in a dime and the White House received 2,680,000 letters within days.

President Franklin Roosevelt meeting with Basil O'Connor

As the fear of polio increased each year, funds to combat it increased from $1.8 million to $67 million by 1955. Research continued during those years, but, writes O'Neill, "everything scientists believed about polio at first was wrong, leading them down many blind alleys... furthermore, most researchers were experimenting with highly dangerous live vaccines. In one test six children were killed and three left crippled."^[5]

"This was the situation when young Jonas Salk, a medical doctor in charge of a virology laboratory at the University of Pittsburgh, decided to use the safer killed virus," writes O'Neill. Despite a general lack of enthusiasm for this approach, O'Connor backed Salk handsomely. After successful tests on laboratory animals, it next had to be tested on human beings. "Who would take the risk?" author Dennis Denenberg asked. "Dr. Jonas Salk did ... along with his wife and children, who also allowed themselves to be human guinea pigs."^[9] In November, 1953, at a national conference in New York's Waldorf-Astoria Hotel, he said, "I will be personally responsible for the vaccine." He announced that his wife and three sons would be among the first volunteers to be inoculated with his vaccine.^[10]

It was critical that he develop the trust of the US public for his experiments and mass tests that would become necessary. An associate of his noted, "That boy really suffers when he sees a paralytic case. You look at him and you see him thinking, 'My God, this can be prevented'."^[11] As a result of his preliminary results in 1954, "when polio was destroying more American children than any other communicable disease, Salk's vaccine was ready for field testing."^[5]

Salk gives test inoculation to his son

Field tests

The tests Salk set up were, according to O'Neill, "the most elaborate program of its kind in history, involving 20,000 physicians and public health officers, 64,000 school personnel, and 220,000 volunteers." A 1954 Gallup poll showed that more Americans knew about the polio field trials than could give the full name of the US President. According to medical author Paul Offit, "more Americans had participated in the funding, development, and testing of the polio vaccine than had participated in the nomination and election of the president."^[12]:54 At least one hundred million people had contributed to the March of Dimes, and seven million had donated their time and labor as well.^[5] They included fund-raisers, committee workers, and volunteers at clinics and record centers.

Doris Fleischer, a disability historian, noted that O'Connor was willing to take whatever risks necessary to serve the purposes of the foundation. She writes, "When O'Connor realized that success seemed imminent, he allowed the foundation to go into debt to finance the final research required to develop the Salk vaccine. His 'passionate' devotion to this task became almost 'obsessive' when his daughter, a mother of five, told him that she had contracted the illness, saying, 'I've gotten some of your polio.' "^[13]

With the hopes of the world upon him, "Salk worked sixteen hours a day, seven days a week, for years...," wrote Denenberg.^[9] It had been, Salk later described, "two and a half years of drudgery and hard work."^[3]:44 The results of the tests were eventually deemed successful and, O'Neill wrote, "Salk had justified Basil O'Connor's faith."^[5]

Discovering a vaccine

Test results announced

On April 12, 1955, Dr. Thomas Francis, Jr., of the University of Michigan, the monitor of the test results, "declared the vaccine to be safe and effective." The announcement was made at the University of Michigan, exactly 10 years to the day after the death of President Roosevelt. Five hundred people, including 150 press, radio, and television reporters, filled the room; 16 television and newsreel cameras stood on a long platform at the back; and 54,000 physicians, sitting in movie theaters across the country, watched the broadcast on closed-circuit television. Eli Lilly paid $250,000 to broadcast the event. Americans turned on their radios to hear the details, department stores set up loudspeakers, and judges suspended trials so that everyone in the courtroom could hear. Europeans listened on the Voice of America. Paul Offit writes about the event:

"The presentation was numbing, but the results were clear: the vaccine worked. Inside the auditorium Americans tearfully and joyfully embraced the results. By the time Thomas Francis stepped down from the podium, church bells were ringing across the country, factories were observing moments of silence, synagogues and churches were holding prayer meetings, and parents and teachers were weeping. One shopkeeper hung a banner on his window: Thank you, Dr. Salk. 'It was as if a war had ended', one observer recalled."^[12]:56

"The report," wrote the New York Times, "was a medical classic." Dr. Francis reported that the vaccinations had been 80 to 90 percent effective on the basis of results in eleven states. Overall, the vaccine was administered to 440,000 children in forty-four states, and the final report required the evaluation of 144,000,000 separate items of information. After the announcement, when asked whether the effectiveness of the vaccine could be improved, Salk said, "Theoretically, the new 1955 vaccines and vaccination procedures may lead to 100 per cent protection from paralysis of all those vaccinated."^[14]

The nation celebrates

receiving award from President Eisenhower

Within minutes of Francis's declaration that the vaccine was safe and effective, the news of the event was carried coast to coast by wire services and radio and television newscasts. According to Debbie Bookchin, "across the nation there were spontaneous celebrations, . . . . business came to a halt as the news spread. The mayor of New York City interrupted a city council meeting to announce the news, adding, 'I think we are all quite proud that Dr. Salk is a graduate of City College.'"^[3]:46 "By the next morning," writes Bookchin, "politicians around the country were falling over themselves trying to figure out ways they could congratulate Salk, with several suggesting special medals and honors be awarded.... In the Eisenhower White House, plans were already afoot to present Salk a special presidential medal designating him "a benefactor of mankind" in a Rose Garden ceremony.

It was also declared "a victory for the whole nation." Jonas Salk became "world famous overnight and was showered with awards," writes O'Neill. The governor of Pennsylvania had a medal struck, and the state legislature gave him a chaired professorship. However, New York City could not get him to accept a ticker tape parade. Instead New York created eight "Jonas Salk Scholarships" for future medical students. He received a Presidential Citation, the nation's first Congressional Medal for Distinguished Civilian Service, and a large number of honorary degrees and related honors.^[5]:138

According to O'Neill, "April 12th had almost become a national holiday: people observed moments of silence, rang bells, honked horns, blew factory whistles, fired salutes, kept their red lights red in brief periods of tribute, took the rest of the day off, closed their schools or convoked fervid assemblies therein, drank toasts, hugged children, attended church, smiled at strangers, and forgave enemies."^[5]:138

By July, movie studios were already fighting for the motion-picture rights to his film biography. Twentieth Century-Fox began writing a screenplay and Warner Brothers filed a claim to the title The Triumph of Dr. Jonas Salk shortly after the formal announcement of the vaccine.^[15]

Global acceptance and hope

Six months before Salk's announcement, optimism and hope were so widespread that the Polio Fund in the U.S. had already contracted to purchase enough of the Salk vaccine to immunize 9,000,000 children and pregnant women the following year.^[16] And around the world, the official news prompted an immediate international rush to vaccinate. Medical historian Debbie Bookchin writes, "Israel had committed to the Salk vaccine just days before the final report was released, and now Canada, Sweden, Denmark, Norway, West Germany, the Netherlands, Switzerland, and Belgium all announced plans to either immediately begin polio immunization campaigns using Salk's vaccine or to gear up to quickly do so. "Overnight," she adds, "Salk had become an international hero and a household name. His vaccine was a modern medical miracle."^[3]:47 Because he was the first to prove that a killed-virus could prevent polio, medical historian Paul Offit wrote in 2007 that "for this observation alone, Salk should have been awarded the Nobel Prize.^[12]

By the summer of 1957, over two years later, 100,000,000 doses had been distributed throughout the United States and "reported complications following their administration have been remarkably rare," noted the scientists at the International Polio Conference in Geneva. Scientists from other nations reported similar experiences: Denmark, for example, "reported only a few sporadic cases among the 2,500,000 ... who received the vaccine." Australia reported virtually no polio during her past summer season.^[17]

Other countries where the vaccine was not yet in use suffered continued epidemics, however. In 1957, Hungary, for example, reported a severe epidemic requiring emergency international assistance. By the first half of the year they had 713 reported cases and a death rate of 6.6%, and the peak infection months of summer were still ahead. Canada sent a shipment of vaccine to Hungary by a refrigerated plane, and Britain and Sweden sent iron lungs. A few years later, during a polio outbreak in Canada, "masked bandits" stole 75,000 Salk vaccine shots from a Montreal university research center.^[18]

New medical research projects urged

Just two weeks after the vaccine was announced, Senator Hubert H. Humphrey, Democrat of Minnesota, urged President Dwight D. Eisenhower "to show the nation's gratitude to Dr. Jonas E. Salk for his new polio vaccine by 'loosening the purse-strings' on Federal medical research."^[19] Salk knew it would take time to verify his theories and improve the vaccine. "He still wants to find out a number of things about polio," wrote the New York Times that summer. Questions remained: "How long will the immunity last? Are there any children who cannot be immunized? What improvements can be made?" Beyond that, "he has far bigger goals - 'more in the nature of dreams right now' - involving other diseases."^[11]

Over the next few years, while trying to perfect the polio vaccine, Salk had begun working unannounced, on a cure for cancer. A 1958 article in the New York Times confirmed "that he had been conducting experiments on cancer patients." The news was leaked after a Pittsburgh newspaper, the Sun-Telegraph, reported that he had been giving injections to children suffering from cancer. Salk stated afterwards, "It is true that we have been conducting experiments in many persons with a variety of cancer and cancer-like conditions ... but we have no treatment for cancer. Our studies are of a strictly exploratory nature..."^[20] In 1965, he also said "a vaccine for the common cold is a matter of time and of solving some technical problems."^[21]

Final conquest of polio and the Sabin vaccine controversy

U.S. postage stamp, 1959

Years before the Salk vaccine was officially announced as safe, Dr. Albert Sabin had also joined in the search for a vaccine, using a live-virus, as opposed to Salk's killed-virus. Sabin, however, had been "openly hostile to Salk." Debbie Bookchin writes that he had been "perhaps accurately guessing that Salk was about to challenge him for ascendancy in the polio world." After one presentation that Salk made to a medical conference, "Sabin mounted a full-scale offensive, engaging in a piecemeal demolition of his presentation."^[3] However, the National Foundation "swiftly put its full weight behind Salk. Here, finally, was a polio researcher, they said, who had accomplished something."^[3]

By 1962 polio had almost become extinct, with only 910 cases reported that year - down from 37,476 in 1954. "It's a matter of principle," Salk said. "It is not a Salk versus Sabin controversy, a competition between two people... I had worked with influenza viruses, helping to establish the efficacy of a killed-virus vaccine... I demonstrated that it could be 100 percent effective if the quantity of virus in the vaccine was sufficient."^[22] That same year the state of New York Health Department recommended "that the Salk vaccine be given preference over the Sabin oral vaccine..."^[23]

On October 20, 1998, after eighteen years of using the Sabin vaccine, however, the federal government recommended that children use the Salk vaccine exclusively. Sabin's polio vaccine is no longer available in the United States.^[12]:127

Looking back - Public confusion over which vaccine to use

In September 1962, public health officials in the U.S. and Canada faced a "major dilemma": whether or not to continue using the recently begun Sabin vaccine inoculations, until further studies were conducted, due to reports of polio cases among persons who had received it. The U.S. Surgeon General, Luther Terry, recommended a temporary halt due to sixteen cases of confirmed polio in adults. And "the Canadian Federal Health Department recommended against mass use of the [Sabin] oral vaccine pending further study of its effects." One of the unfortunate results caused by the controversy was that "many authorities have deplored the confusion that has been created in the public mind."^[24]

Due to the American Medical Association's (AMA) "obstructive tactics, however, which caused numerous delays," writes O'Neill, the AMA had called for mass vaccinations in early 1962 employing Sabin's vaccine rather than Salk's. However, writes O'Neill, "as live-virus was more dangerous, it caused an unknown number of polio cases... [but] the medical establishment seemed not to mind, having gotten its own way at last." But, concludes O'Neill, "polio was conquered all the same, even if not so quickly and safely as it might have been."^[5]:139

In 1980, Salk pointed out the "renewed interest in his killed virus vaccine, particularly in developing countries. "The live virus vaccine is highly effective in developed countries ...," he said, "but in the developing countries, where polio is on the increase, the drawback is that the live virus fails to establish the infection that leads to immunity because of intestinal inhibitors in the population."^[22]

Basil O'Connor enters the controversy

Two months after the Salk vaccine was announced to the world, in 1955, Basil O'Connor found it necessary to respond to critics of the vaccine, especially Dr. Sabin. As the acting president of the National Foundation for Infantile Paralysis, he said, during a news conference before a Congressional group in Washington, that "criticism of the Salk vaccine program by Dr. Albert Sabin of the University of Cincinnati was 'old stuff'." According to the New York Times, "Dr. Sabin recommended at a hearing before a House Investigating subcommittee that Salk inoculations be suspended" until a safer preparation could be perfected.^[25] O'Connor responded in a prepared statement: (excerpt)

"He's been using it [criticism] for years. He used it in an attempt to stop the field trials of the Salk vaccine... The Salk vaccine is safe and effective and will protect children from paralytic polio to the extent of 60 to 90 percent... In the United States, Canada and Denmark, 7,675,000 children have actually received the Salk vaccine with no untoward results. There could be no better proof of its safety than this. No vaccine in the history of the world has ever had such a test for safety. Anyone who would seek to prevent its use for other than unanswerable scientific reasons would be acting neither as a scientist nor as a humanitarian....

"Those who would prevent its use must be prepared to be haunted for life by the crippled bodies of little children who could have been saved from paralysis had they been permitted to receive the Salk vaccine."^[25]

However, a year and a half after the Salk vaccine was introduced, a Sabin vaccine had still not yet been tested on humans. Sabin himself said, in October 1956, that "the Salk vaccine is still the only protection against polio available to the public." He was hoping to be able to start tests on humans by the end of the year or by 1957.^[26]

10th anniversary ceremonies

On April 12, 1965, leaders of the Senate and House presented Salk with a joint resolution expressing the nation's gratitude to him, his colleagues in the project and the March of Dimes, which helped to finance the work. President Lyndon B. Johnson called him to the White House to congratulate him personally. Dr. Luther Terry, Surgeon General of the United States said in a statement marking the anniversary that only 121 cases of polio were reported the previous year, as opposed to more than 28,000 ten years ago. "This represents an historic triumph of preventive medicine - unparalleled in history," Dr. Terry said.^[21]

30th anniversary - "Jonas Salk Day"

On May 6, 1985, President Ronald Reagan proclaimed that day to be "Jonas Salk Day." Text of the proclamation is below:

One of the greatest challenges to mankind always has been eradicating the presence of debilitating disease. Until just thirty years ago poliomyelitis occurred in the United States and throughout the world in epidemic proportions, striking tens of thousands and killing thousands in our own country each year. Dr. Jonas E. Salk changed all that. This year we observe the 30th anniversary of the licensing and manufacturing of the vaccine discovered by this great American. Even before another successful vaccine was discovered, Dr. Salk's discovery had reduced polio and its effects by 97 percent. Today, polio is not a familiar disease to younger Americans, and many have difficulty appreciating the magnitude of the disorder that the Salk vaccine virtually wiped from the face of the earth.

Jonas E. Salk always had a passion for science. It was because of this that he finally chose medicine over law as his career goal. Even after his great discovery, he continued to undertake vital studies and medical research to benefit his fellowman. Under his vision and leadership, the Salk Institute for Biological Studies has been in the forefront of basic biological research, reaping further benefits for mankind and medical science.

In recognition of his tremendous contributions to society, particularly for his role in the epochal discovery of the first licensed vaccine for poliomyelitis, and in celebration of the thirtieth anniversary of its mass distribution, the Congress, by House Joint Resolution 258, has designated May 6, 1985, as "Dr. Jonas E. Salk Day" and authorized and requested the President to issue a proclamation in observance of this event. Now, Therefore, I, Ronald Reagan, President of the United States of America, do hereby proclaim May 6, 1985, as Dr. Jonas E. Salk Day. I urge the people of the United States to observe the day with appropriate tributes, ceremonies, and activities throughout the Nation and by paying honor, at all times, to this outstanding physician and to his life's work. In Witness Whereof, I have hereunto set my hand this sixth day of May, in the year of our Lord nineteen hundred and eighty-five, and of the Independence of the United States of America the two hundred and ninth.^[27]

Becoming a public figure

Celebrity versus privacy

Salk at the University of Pittsburgh

Salk, however, preferred not to have his career as a scientist affected by too much personal attention as he had always tried to remain independent and private in his research and life. But this proved to be impossible. "Young man, a great tragedy has befallen you - you've lost your anonymity," the late television personality Ed Murrow said to Salk shortly after the onslaught of media attention.^[22] When Murrow asked him, "Who owns this patent?", Salk replied, "No one. Could you patent the sun?" ^[28]

Author Jon Cohen noted that "Jonas Salk made scientists and journalists alike go goofy. As one of the only living scientists whose face was known the world over, Salk, in the public's eye, had a superstar aura. Airplane pilots would announce that he was on board, and passengers would burst into applause. Hotels routinely would upgrade him into their penthouse suites. A meal at a restaurant inevitably meant an interruption from an admirer... and scientists approached him with drop-jawed wonder, as though some of the stardust might rub off."^[29]

For the most part, however, Salk was "appalled at the demands on the public figure he has become and resentful of what he considers to be the invasion of his privacy," wrote the New York Times, a few months after his vaccine announcement.^[11] The Times article noted that "at 40, the once obscure scientist ... was lifted from his laboratory almost to the level of a folk hero." He received a Presidential citation, a score of awards, four honorary degrees, half a dozen foreign decorations, and letters from thousands of fellow citizens. His alma mater, City College of New York, gave him an honorary degree as Doctor of Laws. But "despite such very nice tributes," the New York Times wrote, "Salk is profoundly disturbed by the torrent of fame that has descended upon him.... He talks continually about getting out of the limelight and back to his laboratory... because of his genuine distaste for publicity, which he believes is inappropriate for a scientist."^[11]

During a 1980 interview, 25 years later, he said, "It's as if I've been a public property ever since, having to respond to external as well as internal impulses.... It's brought me enormous gratification, opened many opportunities, but at the same time placed many burdens on me. It altered my career, my relationships with colleagues; I am a public figure, no longer one of them."^[22]

Maintaining his individuality

"If Salk the scientist sounds austere," wrote the New York Times, "Salk the man is a person of great warmth and tremendous enthusiasm. People who meet him generally like him." A Washington newspaper correspondent commented, "He could sell me the Brooklyn Bridge, and I never bought anything before." Award-winning geneticist Walter Nelson-Rees called him "a renaissance scientist: brilliant, sophisticated, driven... a fantastic creature."^[30]:127

He enjoys talking to people he likes, and "he likes a lot of people," wrote the Times. "He talks quickly, articulately, and often in complete paragraphs." And, notes the Times, "He has very little perceptible interest in the things that interest most people - such as making money." That belongs "in the category of mink coats and Cadillacs - unnecessary," he said.^[11]

Establishing the Salk Institute

In the years after his discovery, many supporters, in particular the National Foundation, "helped him build his dream of a research complex for the investigation of biological phenomena 'from cell to society'." It was called the Salk Institute for Biological Studies and opened in 1963 at La Jolla, California, just outside San Diego. Salk believed that the institution would help new and upcoming scientists along their careers as he said himself, “I thought how nice it would be if a place like this existed and I was invited to work there." This was something that Salk was deprived of early in his life, but due to his achievements, was able to provide for future scientists.

In 1966, Salk described his "ambitious plan for the creation of a kind of Socratic academy where the supposedly alienated two cultures of science and humanism will have a favorable atmosphere for cross-fertilization."^[31] Author and journalist Howard Taubman explained:

"Although he is distinctly future-oriented, Dr. Salk has not lost sight of the institute's immediate aim, which is the development and use of the new biology, called molecular and cellular biology, described as part physics, part chemistry and part biology. The broad-gauged purpose of this science is to understand man's life processes.

"There is talk here of the possibility, once the secret of how the cell is triggered to manufacture antibodies is discovered, that a single vaccine may be developed to protect a child against many common infectious diseases. There is speculation about the power to isolate and perhaps eliminate genetic errors that lead to birth defects.

"Dr. Salk, a creative man himself, hopes that the institute will do its share in probing the wisdom of nature and thus help enlarge the wisdom of man. for the ultimate purpose of science, humanism and the arts, in his judgment, is the freeing of each individual to cultivate his full creativity, in whichever direction it leads. . . As if to prepare for Socratic encounters such as these, the institute's architect, Louis Kahn, has installed blackboards in place of concrete facings on the walls along the walks. "^[31]

The New York Times, in a 1980 article celebrating the 25th anniversary of the Salk vaccine, described the current workings at the facility:

"At the institute, a magnificent complex of laboratories and study units set on a bluff overlooking the Pacific, Dr. Salk holds the titles of founding director and resident fellow. His own laboratory group is concerned with the immunologic aspects of cancer and the mechanisms of autoimmune disease, such as multiple sclerosis, in which the immune system attacks the body's own tissues.^[22]

In an interview about his future hopes at the institute, he said, "In the end, what may have more significance is my creation of the institute and what will come out of it, because of its example as a place for excellence, a creative environment for creative minds."

Beginning in the early 1980s, Salk also engaged in research to develop a vaccine for another, more recent plague, AIDS. To further this research, he co-founded The Immune Response Corporation with Kevin Kimberlin, to search for a vaccine, and patented Remune, an immune-based therapy.^[32] It has not yet been evaluated by the U.S. Food and Drug Administration (FDA) for use by people living with HIV, however.

Salk died, at age eighty-one, before a successful vaccine was found, and although many advances were made in treating AIDS, "the world still waited for the miracle vaccine the conqueror of polio had sought," wrote historian Alan Axelrod.^[33]:294

Salk's "biophilosophy"

Jonas Salk during a 1988 Centers for Disease Control visit

In 1966, the New York Times referred to him as the "Father of Biophilosophy." According to Times journalist and author Howard Taubman, "he never forgets... there is a vast amount of darkness for man to penetrate. As a biologist, he believes that his science is on the frontier of tremendous new discoveries; and as a philosopher, he is convinced that humanists and artists have joined the scientists to achieve an understanding of man in all his physical, mental and spiritual complexity. Such interchanges might lead, he would hope, to a new and important school of thinkers he would designate as biophilosophers."^[31]

Salk describes his "biophilosophy" as the application of a "biological, evolutionary point of view to philosophical, cultural, social and psychological problems." He went into more detail in two of his books, Man's Unfolding, and The Survival of the Wisest. In an interview in 1980, he described his thoughts on the subject, including his feeling that a sharp rise and an expected leveling off in the human population would take place and eventually bring a change in human attitudes:

"I think of biological knowledge as providing useful analogies for understanding human nature. . . People think of biology in terms of such practical matters as drugs, but its contribution to knowledge about living systems and ourselves will in the future be equally important. . . In the past epoch, man was concerned with death, high mortality; his attitudes were antideath, antidisease," he says. "In the future, his attitudes will be expressed in terms of prolife and prohealth. The past was dominated by death control; in the future, birth control will be more important. These changes we're observing are part of a natural order and to be expected from our capacity to adapt. It's much more important to cooperate and collaborate. We are the co-authors with nature of our destiny."^[22]

His definition of a "bio-philosopher" is "Someone who draws upon the scriptures of nature, recognizing that we are the product of the process of evolution, and understands that we have become the process itself, through the emergence and evolution of our consciousness, our awareness, our capacity to imagine and anticipate the future, and to choose from among alternatives."^[34]

Personal life

Salk's grave at El Camino

The day after his graduation from medical school, Salk married Donna Lindsay Calfin, a master's candidate at the New York College of Social Work. David Oshinsky writes that her father, Elmer Lindsay, "a wealthy Manhattan dentist, viewed Salk as a social inferior, several cuts below Donna's former suitors." Eventually, her father agreed to the marriage on two conditions: first, Salk must wait until he could be listed as an official M.D. on the wedding invitations, and second, he must improve his "rather pedestrian status" by giving himself a middle name."^[2]

They had three children: Peter, Darrell, and Jonathan. In 1968, they divorced, and in 1970 Salk married Françoise Gilot, the former mistress of Pablo Picasso.

Jonas Salk died on June 23, 1995 in La Jolla and was buried at El Camino Memorial Park San Diego^[35]

Honors and recognition

President Carter gives Medal of Freedom to Jonas Salk, 1977

• 1955, one month after the vaccine announcement, he was honored by the State of Pennsylvania, where he was given their "highest award for services" by Governor George M. Leader, Meritorious Service Medal, where the governor added,

"... in recognition of his 'historical medical' discovery... Dr. Salk's achievement is meritorious service of the highest magnitude and dimension for the commonwealth, the country and mankind." The governor, who had three children, said that "as a parent he was 'humbly thankful to Dr. Salk,' and as Governor, 'proud to pay him tribute'."^[36]

• 1955, City University of New York city creates the Salk Scholarship fund which it awards to multiple outstanding pre-med students each year
• 1956, awarded the Lasker Award;
• 1958, awarded the James D. Bruce Memorial Award;

Salk's bronze bust in the Polio Hall of Fame

• 1958, elected to the Polio Hall of Fame, which was dedicated in Warm Springs, Georgia;
• 1975, awarded the Jawaharlal Nehru Award and the Congressional Gold Medal;
• 1976, named the Humanist of the Year by the American Humanist Association;
• 1977, awarded the Presidential Medal of Freedom from President Jimmy Carter, with the following statement accompanying the medal:

"Because of Doctor Jonas E. Salk, our country is free from the cruel epidemics of poliomyelitis that once struck almost yearly. Because of his tireless work, untold hundreds of thousands who might have been crippled are sound in body today. These are Doctor Salk's true honors, and there is no way to add to them. This Medal of Freedom can only express our gratitude, and our deepest thanks."^[37]

• 1996, The March of Dimes Foundation created an annual $250,000 cash "Prize" to outstanding biologists as a tribute to Salk [1]
• 2007, California Governor Arnold Schwarzenegger and First Lady Maria Shriver inducted Salk into the California Hall of Fame^[38]

• There are schools in Mesa, Arizona; Tulsa, Oklahoma; Bolingbrook, Illinois; Levittown, New York; Old Bridge, New Jersey and Sacramento, California named for him.

Salk's book publications

• Man Unfolding (1972)
• Survival of the Wisest (1973)
• World Population and Human Values: A New Reality (1981)
• Anatomy of Reality (1983)

References

External links

Wikimedia Commons has media related to: Jonas Salk

Wikiquote has a collection of quotations related to: Jonas Salk

• "Legacy of Salk Institute", video, 30 minutes, history of Salk vaccine
• "Polio Vaccine" intro., Brittanica, video, 1 minute
• The Time 100 The Most Important People of the Century
• Jonas Salk Trust
• Salk Institute for Biological Studies
• Documents regarding Jonas Salk and the Salk Polio Vaccine, Dwight D. Eisenhower Presidential Library
• 1985 Open Mind interview with Richard D. Heffer: Man Evolving...
• University of Pittsburgh Jonas Salk site
• Pittsburgh Post-Gazette feature on Jonas Salk and the Polio cure 50 years later
• The Salk School of Science (New York, NY)
• Patent US Patent 5,256,767 : Vaccine against HIV