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For more information on Julius Wagner-Jauregg, visit Britannica.com.
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| Scientist: Julius Wagner-Jauregg |
Austrian psychiatrist (1857–1940)
Wagner-Jauregg was born at Wels in Austria and educated at the University of Vienna, where he gained his MD in 1880. Finding it difficult to obtain an academic post in orthodox medicine, he turned to psychiatry in 1883 and in 1889 succeeded Krafft-Ebbing as professor of psychiatry at the University of Graz. In 1893 he returned to Vienna as director of the Psychiatric and Neurological Clinic, where he remained until his retirement in 1928.
In 1917 he proposed a new treatment for general paralysis of the insane (GPI), then a relatively common complication of late syphilis. As early as 1887 he had noticed that rare cases of remission were often preceded by a feverish infection, suggesting that the deliberate production of a fever could have a similar effect. Consequently, in 1917 he inoculated nine GPI patients with tertian malaria – a form of malaria that gives a two-day interval between fever attacks. He later reported that in six of these patients extensive remissions had taken place. It was for this work that Wagner-Jauregg received the Nobel Prize for physiology or medicine in 1927. Although therapeutic malaria inoculations were used in the treatment of GPI for some time, demand for them ceased with the discovery of penicillin.
Wagner-Jauregg also proposed in 1894 that cretinism, a thyroid deficiency disease, could be successfully controlled by iodide tablets.
| Columbia Encyclopedia: Julius Wagner-Jauregg |
| Medical Dictionary: Wag·ner von Jau·regg |
Austrian neurologist and psychiatrist. He shared a 1927 Nobel Prize for using a malaria inoculation in the treatment of general paralysis.
| Wikipedia: Julius Wagner-Jauregg |
Julius Wagner-Jauregg, (March 7, 1857 Wels, Upper Austria – September 27, 1940 Vienna) was an Austrian physician.[1]
He studied Medicine at the University of Vienna from 1874 to 1880, where he also studied with Salomon Stricker in the Institute of General and Experimental Pathology, obtaining his doctor's degree in 1880. From 1883 to 1887 he worked with Maximilian Leidesdorf in the Psychiatric Clinic, although his original training was not in the pathology of the nervous system. In 1889 he succeeded the famous Richard von Krafft-Ebing at the Neuro-Psychiatric Clinic of the University of Graz, and started his research on Goitre, cretinism and iodine. In 1893 he became Extraordinary Professor of Psychiatry and Nervous Diseases, and Director of the Clinic for Psychiatry and Nervous Diseases in Vienna, as successor to Theodor Meynert. Ten years later, in 1902, Wagner-Jauregg moved to the psychiatric clinic at the General Hospital and in 1911 he returned to his former post.
The main work pursued by Wagner-Jauregg throughout his life was related to the treatment of mental disease by inducing a fever, an approach known as pyrotherapy. In 1887 he investigated the effects of febrile diseases on psychoses, making use of erisipela and tuberculin (discovered in 1890 by Robert Koch). Since these methods of treatment did not work very well, he tried in 1917 the inoculation of malaria parasites, which proved to be very successful in the case of dementia paralytica (also called general paresis of the insane), caused by neurosyphilis.[2] This discovery earned him the Nobel Prize in Medicine in 1927. His main publication was a book titled Verhütung und Behandlung der progressiven Paralyse durch Impfmalaria (Prevention and treatment of progressive paralysis by malaria inoculation) in the Memorial Volume of the Handbuch der experimentellen Therapie, (1931).
In 1928, Wagner-Jauregg retired from his post but remained active and in good health until his death on September 27, 1940.
Although many schools, roads and hospitals are named after him in Austria, a 2004 review of his life brought to light that not long before his death he made an application to join the Nazi party (which was not endorsed, due to the fact that his first wife had been Jewish) and had strongly advocated the idea of "racial purity" before that.[3]
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