Brain damage due to sustained elevations of bilirubin...no exact number on it....combination of factors...trauma due to birth (pre-hepatic) and immature liver (hepatic)

Kernicterus-- A potentially lethal disease of newborns caused by excessive accumulation of the bile pigment bilirubin.

kernicterus, a form of brain damage. Signs of severe hyperbilirubinemia include listlessness, high-pitched crying, apnea (periods of not breathing), arching of the back, and seizures

There is a possibility to cause oaf for those who takes sulfamethoxazole within the early 16 pregnant weeks, and kernicterus if the medicine is used several weeks before the pregnant is braught to bed. Therefore, it should only be used for the middle pregnant period.

In about 15% of cases, the baby is severely affected and dies before birth. Babies who survive pregnancy may develop kernicterus, which can lead to deafness, speech problems, cerebral palsy, or mental retardation.