It was not a 'lady' but a young man named Eutychus(Acts 20:7-12)
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Macbeth and lady Macbeth try to avoid suspicion by getting into
their pajamas after committing the murder so people will think they
were asleep all the time.
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Macbeth and Lady Macbeth plan to murder King Duncan by inviting him to their castle as guests, then waiting until he is asleep to kill him. They plan to frame the chamberlains for the murder by planting the murder weapons on them.