The largest cities in the US are in the following order:
1. New York, New York State- Largest city in the nation and the North East
2. Los Angelos, California- largest city in the west
3. Chicago, Illinois- largest city in the North.
4. Houston, Texas- Largest city in Texas and the general south
So there you go, the Largest city in the south is Houston In TexasAnthony Owiso