n
An increase R in normal or abnormal white blood cells in nonleukemic conditions; simulates myelogenous, lymphatic, and rarely, monocytic leukemia.
| Dental Dictionary: leukemoid reaction |
An increase R in normal or abnormal white blood cells in nonleukemic conditions; simulates myelogenous, lymphatic, and rarely, monocytic leukemia.
| 5min Related Video: Leukemoid reaction |
| Medical Dictionary: leukemoid reaction |
A moderate, advanced, or sometimes extreme degree of leukocytosis that is similar or possibly identical to that occurring in leukemia but is due to some other cause.
| Wikipedia: Leukemoid reaction |
| Leukemoid reaction | |
|---|---|
| Classification and external resources | |
| ICD-10 | D72.8 |
| ICD-9 | 288.62 |
| DiseasesDB | 30101 |
| MedlinePlus | 000575 |
| MeSH | [1] |
The term leukemoid reaction, also referred to as transient myeloproliferative disorder, describes an elevated white blood cell count, or leukocytosis, that is a physiologic response to stress or infection (as opposed to a primary blood malignancy, such as leukemia).
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Conventionally, a leukocytosis exceeding 50,000 WBC/mm3 with a significant increase in early neutrophil precursors is referred to as a leukemoid reaction.[1] The peripheral blood smear may show myelocytes, metamyelocytes, promyelocytes, and even myeloblasts; however, there is a mix of early mature neutrophil precursors, in contrast to the immature forms typically seen in acute leukemia. Serum leukocyte alkaline phosphatase is elevated in leukemoid reaction, but is depressed in chronic myelogenous leukemia. The bone marrow in a leukemoid reaction, if examined, may be hypercellular but is otherwise typically unremarkable.
Leukemoid reactions are generally benign and are not dangerous in and of themselves, although they are often a response to a significant disease state (see Causes below). However, leukemoid reactions can resemble more serious conditions such as chronic myelogenous leukemia (CML), which can present with identical findings on peripheral blood smear.
Historically, various clues including the leukocyte alkaline phosphatase score and the presence of basophilia were used to distinguish CML from a leukemoid reaction. However, at present the test of choice in adults to distinguish CML is an assay for the presence of the Philadelphia chromosome, either via cytogenetics and FISH, or via PCR for the BCR/ABL fusion gene. The LAP (Leukocyte Alkaline Phosphatase) score is high in reactive states but is low in CML. In cases where the diagnosis is uncertain, a qualified hematologist or oncologist should be consulted.
As noted above, a leukemoid reaction is typically a response to an underlying medical issue. Causes of leukemoid reactions include:
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This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
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