Lipophilic is a substance that dissolves in or mix consistently with lipids.

An unionized drug tends to be lipophilic (and hence, would be hydrophobic). Thus, an ionized drug on the other hand would be lipophobic (i.e. the opposite of lipophilic), lipid-hating.

the nature of interaction depends on whether they are lipophilic or hydrophilic.

if both are hydorphilic ionic interaction, both lipophilic hydrogen bonding. ionic if lipophilic-hydrophilic.

the nature of interaction depends on whether they are lipophilic or hydrophilic.

if both are hydorphilic ionic interaction, both lipophilic hydrogen bonding. ionic if lipophilic-hydrophilic.

Drugs which are administered percutaneously, sublingually, or have to cross the blood brain barrier have to be lipophilic.