Generally yes. F5 is the strongest category of tornado capable
of completely obliterating well built structures. However how bad a
tornado is depends on factors other than strength, such as where
the tornado hits. For example, a number of F5 tornadoes have
traveled over open country, with the worst damage limited to farms
that were destroyed.
A list of the worst tornadoes in U.S. history will consist
mostly of F5 or EF5 tornadoes (including the #1 worst), but several
F4 tornadoes would be on that list as well.