malignancy

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(mə-lĭg'nən-sē) pronunciation
n., pl., -cies.
  1. also ma·lig·nance (-nəns) The state or quality of being malignant.
  2. Pathology. A malignant tumor.

A tendency to progress in virulence. In popular usage, any condition that, if uncorrected, tends to worsen so as to cause serious illness or death. Cancer is the best known example.

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metastatic capacity (medicine)