Why formaldehyde use in mannich base reaction

No, although an imine is prepared in situ in a mannich reaction. A schiff base can be prepared when a starting primary amine reacts with a ketone or aldehyde and liberates a water molecule.

The main applications for the Mannich reaction can be found in natural compounds such as peptides and antibiotics. Other forms are paint and medicinal compounds, such as certain anti-inflammatory drugs or anti-depressants.

Carl Mannich was born on 1877-03-08.

Carl Mannich died on 1947-03-05.