Why formaldehyde use in mannich base reaction

No, Schiff base is not prepared by Mannich reaction. Schiff base is typically formed through the condensation reaction between a primary amine and a carbonyl compound. Mannich reaction, on the other hand, involves the condensation of a primary or secondary amine, a carbonyl compound, and formaldehyde or a derivative.

The main applications for the Mannich reaction can be found in natural compounds such as peptides and antibiotics. Other forms are paint and medicinal compounds, such as certain anti-inflammatory drugs or anti-depressants.

Carl Mannich was born on 1877-03-08.

Carl Mannich died on 1947-03-05.