Lymphoma is a cancer of the tissue of the lymphatic system. There are two categories of lymphomas. One type is termed Hodgkin's disease, the other, non-Hodgkin's lymphoma

Any of a group of malignant diseases that usually start in the lymph nodes or lymphoid tissues. The two major types, Hodgkin disease and non-Hodgkin lymphoma, each have several subtypes. Diagnosis of either type requires biopsy, usually from the lymph nodes. Non-Hodgkin lymphomas may be diffuse (widespread) or nodular (concentrated in nodules); nodular lymphomas generally develop more slowly.

The first symptom of non-Hodgkin's lymphoma is often a painless swelling of a lymph node in the neck, the groin, or under the arm. Other symptoms include fever, night sweats, itching, and unexplained weight loss. Diagnosis is made by laboratory study of tissue obtained by taking a biopsy of the suspicious lymph node or nodes.

Lymphoma, non-Hodgkin's, any cancer of the lymphoid tissue in which the Reed-Sternberg cells characteristic of Hodgkin's disease (the other category of lymphoma) are not present. There are about 10 different types of non-Hodgkin's lymphomas, some slower- or faster-growing than others. Non-Hodgkin's lymphoma can affect children as well as adults. In most cases the cause is unknown, but an increased incidence has been observed in people who have been exposed to Agent Orange, and some forms of the disease are frequently seen in people with AIDS, many of these in association with latent Epstein-Barr virus infection.

Treatment

Treatment depends on how far the disease has progressed. It may include external-beam radiation therapy, chemotherapy, or biological therapy (boosting the body's immune response to the disease). Rituxan, a genetically engineered drug involving monoclonal antibodies, has been approved for use against some low-grade (slow-growing) non-Hodgkin's lymphoma.

Bone marrow transplantation is also sometimes used. In this technique, bone marrow (blood cell-producing tissue inside bone) is taken from the patient and treated to kill any cancer cells. The patient is then given very high dose chemotherapy designed to destroy the cancer; it also destroys the remaining bone marrow. After chemotherapy, the stored marrow is reinserted into the patient. In children, chemotherapy is the most common treatment.

http://www.cms.hhs.gov/ICD9ProviderDiagnosticCodes/Downloads/new_diagnosis_codes_2007.pdf

Table 6A - New Diagnosis Codes

Effective October 1, 2007

Note: The final addendum providing complete information on changes to the diagnosis part of ICD-9-CM is posted on CDC's webpage at: www.cdc.gov/nchs/icd9.htm. Diagnosis Code

Description

040.41

Infant botulism

040.42

Wound botulism

058.10

Roseola infantum, unspecified

058.11

Roseola infantum due to human herpesvirus 6

058.12

Roseola infantum due to human herpesvirus 7

058.21

Human herpesvirus 6 encephalitis

058.29

Other human herpesvirus encephalitis

058.81

Human herpesvirus 6 infection

058.82

Human herpesvirus 7 infection

058.89

Other human herpesvirus infection

079.83

Parvovirus B19

200.30

Marginal zone lymphoma, unspecified site, extranodal and solid organ sites

200.31

Marginal zone lymphoma, lymph nodes of head, face, and neck

200.32

Marginal zone lymphoma, intrathoracic lymph nodes

200.33

Marginal zone lymphoma, intraabdominal lymph nodes

200.34

Marginal zone lymphoma, lymph nodes of axilla and upper limb

200.35

Marginal zone lymphoma, lymph nodes of inguinal region and lower limb

200.36

Marginal zone lymphoma, intrapelvic lymph nodes

200.37

Marginal zone lymphoma, spleen

200.38

Marginal zone lymphoma, lymph nodes of multiple sites

200.40

Mantle cell lymphoma, unspecified site, extranodal and solid organ sites

200.41

Mantle cell lymphoma, lymph nodes of head, face, and neck

200.42

Mantle cell lymphoma, intrathoracic lymph nodes

200.43

Mantle cell lymphoma, intra-abdominal lymph nodes

200.44

Mantle cell lymphoma, lymph nodes of axilla and upper limb

200.45

Mantle cell lymphoma, lymph nodes of inguinal region and lower limb

200.46

Mantle cell lymphoma, intrapelvic lymph nodes

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