Marshall Warren Nirenberg

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Marshall Warren Nirenberg

Library of Congress (AP photo)

[b. New York City, April 10, 1927]

In 1961 Nirenberg became the first person to determine what one letter of the genetic code stands for, using RNA. This opened the way for Nirenberg and colleagues to crack the genetic code completely by 1966, demonstrating which sequence of three nucleotide bases (a codon) determined each of 20 amino acids, along with similar three-letter codes for start and stop.

Marshall Warren Nirenberg (born 1927) is best known for deciphering the portion of DNA (deoxyribonucleic acid) that is responsible for the synthesis of the numerous protein molecules which form the basis of living cells. In 1968 he was awarded the Nobel Prize for physiology or medicine.

Nirenberg's research has helped to unravel the DNA genetic code, aiding, for example, in the determination of which genes code for certain hereditary traits. For his contribution to the sciences of genetics and cell biochemistry, Nirenberg was awarded the 1968 Nobel Prize in physiology or medicine with Robert W. Holley and Har Gobind Khorana.

Nirenberg was born in New York City on April 10, 1927, and moved to Florida with his parents, Harry Edward and Minerva (Bykowsky) Nirenberg, when he was ten years old. He earned his B.S. in 1948 and his M.Sc. in biology in 1952 from the University of Florida. Nirenberg's interest in science extended beyond his formal studies. For two of his undergraduate years he worked as a teaching assistant in biology, and he also spent a brief period as a research assistant in the nutrition laboratory. In 1952, Nirenberg continued his graduate studies at the University of Michigan, this time in the field of biochemistry. Obtaining his Ph.D. in 1957, he wrote his dissertation on the uptake of hexose, a sugar molecule, by ascites tumor cells.

Shortly after earning his Ph.D., Nirenberg began his investigation into the inner workings of the genetic code as an American Cancer Society (ACS) fellow at the National Institutes of Health (NIH) in Bethesda, Maryland. Nirenberg continued his research at the NIH after the ACS fellowship ended in 1959, under another fellowship from the Public Health Service (PHS). In 1960, when the PHS fellowship ended, he joined the NIH staff permanently as a research scientist in biochemistry.

After only a brief time conducting research at the NIH, Nirenberg made his mark in genetic research with the most important scientific breakthrough since James D. Watson and Francis Crick discovered the structure of DNA in 1953. Specifically, he discovered the process for unraveling the code of DNA. This process allows scientists to determine the genetic basis of particular hereditary traits. In August of 1961, Nirenberg announced his discovery during a routine presentation of a research paper at a meeting of the International Congress of Biochemistry in Moscow.

Nirenberg's research involved the genetic code sequences for amino acids. Amino acids are the building blocks of protein. They link together to form the numerous protein molecules present in the human body. Nirenberg discovered how to determine which sequences patterns code for which amino acids (there are about 20 known amino acids).

Nirenberg's discovery has led to a better understanding of genetically determined diseases and, more controversially, to further research into the controlling of hereditary traits, or genetic engineering. For his research, Nirenberg was awarded the 1968 Nobel Prize for physiology or medicine. He shared the honor with scientists Har Gobind Khorana and Robert W. Holley. After receiving the Nobel Prize, Nirenberg switched his research focus to other areas of biochemistry, including cellular control mechanisms and the cell differentiation process.

Since first being hired by the NIH in 1960, Nirenberg has served in different capacities. From 1962 until 1966 he was Head of the Section for Biochemical Genetics, National Heart Institute. Since 1966 he has been serving as the Chief of the Laboratory of Biochemical Genetics, National Heart, Lung and Blood Institute. Other honors bestowed upon Nirenberg, in addition to the Nobel Prize, include honorary membership in the Harvey Society, the Molecular Biology Award from the National Academy of Sciences (1962), National Medal of Science presented by President Lyndon B. Johnson (1965), and the Louisa Gross Horwitz Prize for Biochemistry (1968). Nirenberg also received numerous honorary degrees from distinguished universities, including the University of Michigan (1965), University of Chicago (1965), Yale University (1965), University of Windsor (1966), George Washington University (1972), and the Weizmann Institute in Israel (1978). Nirenberg is a member of several professional societies, including the National Academy of Sciences, the Pontifical Academy of Sciences, the American Chemical Society, the Biophysical Society, and the Society for Developmental Biology.

Nirenberg married biochemist Perola Zaltzman in 1961. While described as being a reserved man who engages in little else besides scientific research, Nirenberg has been a strong advocate of government support for scientific research, believing this to be an important factor for the advancement of science.

Further Reading

Wasson, Tyler, editor, Nobel Prize Winners, H. W. Wilson, 1987, pp. 767-768.

New York Times, October 12, 1982, p. C3.

Marshall Warren Nirenberg
Marshall Warren Nirenberg
Born	April 10, 1927 (age 81)
Nationality	U.S.
Alma mater	University of Michigan
Known for	genetic code
Notable awards	Nobel Prize in Physiology or Medicine in 1968

Marshall Warren Nirenberg (born April 10, 1927) is a U.S. biochemist and geneticist. He shared a Nobel Prize in Physiology or Medicine in 1968 with Har Gobind Khorana and Robert W. Holley for describing the genetic code and how it operates in protein synthesis. In the same year, together with Har Gobind Khorana, he was awarded the Louisa Gross Horwitz Prize from Columbia University.

Contents 1 Research 2 Biography 3 Notes 4 References 5 Further reading

Research

By 1959, experiments and analysis such as the Avery-MacLeod-McCarty experiment, the Hershey-Chase experiment, the Watson-Crick structure and the Meselson-Stahl experiment had shown DNA to be the molecule of genetic information. It was not known, however, how DNA directed the expression of proteins, or what role RNA had in these processes. Nirenberg teamed up with Heinrich J. Matthaei at the National Institutes of Health to answer these questions. They produced RNA comprised solely of uracil, a nucleotide that only occurs in RNA. They then added this synthetic poly-uracil RNA into a cell-free extract of Escherichia coli which contained the DNA, RNA, ribosomes and other cellular machinery for protein synthesis. They added DNase, which breaks apart the DNA, so that no additional proteins would be produced other than that from their synthetic RNA. They then added 1 radioactively labeled amino acid, the building blocks of proteins, and 19 unlabeled amino acids to the extract, varying the labeled amino acid in each sample. In the extract containing the radioactively labeled phenylalanine, the resulting protein was also radioactive. They realized that they had found the genetic code for phenylalanine: UUU (three uracil bases in a row) on RNA. This was the first step in deciphering the codons of the genetic code and the first demonstration of messenger RNA (see Nirenberg and Matthaei experiment).^{[1][2][3][4][5][6][7]}

Nirenberg received great scientific attention for these experiments. Within a few years, his research team had performed similar experiments and found that three-base repeats of adenosine (AAA) produced the amino acid lysine, cytosine repeats (CCC) produced proline and guanine repeats (GGG) produced glycine. The next breakthrough came when Philip Leder, a postdoctoral researcher in Nirenberg's lab, developed a method for determining the genetic code on pieces of tRNA (see Nirenberg and Leder experiment). This greatly sped up the assignment of three-base codons to amino acids so that 50 codons were identified in this way. Khorana's experiments confirmed these results and completed the genetic code translation.

Nirenberg's later research focused on neuroscience, neural development, and the homeobox genes.

Biography

Nirenberg was born in New York City, the son of Harry and Minerva Nirenberg. He developed rheumatic fever as a boy, so the family moved to Orlando, Florida to take advantage of the subtropical climate. He developed an early interest in biology. In 1948 he received his B.S. degree, and in 1952, a master's degree in zoology from the University of Florida at Gainesville. His dissertation for the Master's thesis was an ecological and taxonomic study of caddis flies (Trichoptera). He received his Ph.D. in biochemistry from the University of Michigan, Ann Arbor in 1957.

He began his postdoctoral work at the National Institutes of Health (NIH) in 1957 as a fellow of the American Cancer Society. In 1960 became a research biochemist at the NIH. In 1959 he began to study the steps that relate DNA, RNA and protein. Nirenberg's groundbreaking experiments advanced him to become the head of the Section of Biochemical Genetics in 1962. He was married in 1961 to Perola Zaltzman, a chemist from the University of Brazil, Rio de Janeiro.

Nirenberg was awarded the National Medal of Science in 1966 and the National Medal of Honor in 1968 by President Lyndon B. Johnson. He was elected to the American Philosophical Society in 2001.

Notes

1. ^ Leder, P; Nirenberg, M W (1964), "RNA Codewords and Protein Synthesis, 3. On the Nucleotide Sequence of a Cysteine and a Leucine RNA Codeword.", Proceedings of the National Academy of Sciences 52: 1521–1529, 1964 December, doi:10.1073/pnas.52.6.1521, PMID 14243527, http://www.pnas.org/cgi/reprint/52/6/1521 
2. ^ Eiserling, F; Levin, J G; Byrne, R; Karlsson, U (1964), "Polyribosomes and DNA-dependent Amino Acid Incorporation in Escherichia coli Extracts.", Journal of Molecular Biology 10: 536–40, 1964 December, doi:10.1016/S0022-2836(64)80073-5, PMID 14257696 
3. ^ BLADEN, H A; BYRNE, R; LEVIN, J G; NIRENBERG, M W (1965), "AN ELECTRON MICROSCOPIC STUDY OF A DNA-RIBOSOME COMPLEX FORMED IN VITRO.", J. Mol. Biol. 11: 78–83, 1965 Jan, doi:10.1016/S0022-2836(65)80172-3, PMID 14255762 
4. ^ BERNFIELD, M R; NIRENBERG, M W (1965), "RNA CODEWORDS AND PROTEIN SYNTHESIS. THE NUCLEOTIDE SEQUENCES OF MULTIPLE CODEWORDS FOR PHENYLALANINE, SERINE, LEUCINE, AND PROLINE.", Science 147: 479–84, 1965 Jan 29, doi:10.1126/science.147.3657.479, PMID 14237203 
5. ^ TRUPIN, J S; ROTTMAN, F M; BRIMACOMBE, R L; LEDER, P (1965), "RNA CODEWORDS AND PROTEIN SYNTHESIS, VI. ON THE NUCLEOTIDE SEQUENCES OF DEGENERATE CODEWORD SETS FOR ISOLEUCINE, TYROSINE, ASPARAGINE, AND LYSINE.", Proc. Natl. Acad. Sci. U.S.A. 53: 807–11, 1965 Apr, doi:10.1073/pnas.53.4.807, PMID 14324538 
6. ^ Jones, O W; Nirenberg, M W (1966), "Degeneracy in the amino acid code.", Biochim. Biophys. Acta 119 (2): 400–6, 1966 May 19, PMID 5335948 
7. ^ Kellogg, D A; Doctor, B P; Loebel, J E; Nirenberg, M W (1966), "RNA codons and protein synthesis. IX. Synonym codon recognition by multiple species of valine-, alanine-, and methionine-sRNA.", Proc. Natl. Acad. Sci. U.S.A. 55 (4): 912–9, 1966 Apr, doi:10.1073/pnas.55.4.912, PMID 5327071 

References

• Voet, Donald and Judith G. Voet. 1995. Biochemistry 2nd ed. John Wilely & Sons, New York.
• U.S. National Library of Medicine. "Profiles in Science: The Marshall W. Nirenberg Papers." [1]

Further reading

• Nobel Biography
• NIH Profiles in Science
• Free to View Video Interview with Marshall W. Nirenberg provided by the Vega Science Trust.
• The Official Site of Louisa Gross Horwitz Prize
• Ed Regis (November 2007), "The Forgotten Code Cracker" (print), Scientific American (Scientific American, Inc.): pp. 50–51, "(subtitle) In the 1960's Marshall W. Nirenberg deciphered the genetic code, the combination of A, T, G and C nucleotides that specify amino acids. So why do people think that Francis Crick did it?" 

v • d • e Nobel Laureates in Physiology or Medicine Max Theiler (1951) · Selman Waksman (1952) · Hans Krebs / Fritz Lipmann (1953) · John Enders / Thomas Weller / Frederick Robbins (1954) · Hugo Theorell (1955) · André Cournand / Werner Forssmann / Dickinson W. Richards (1956) · Daniel Bovet (1957) · George Beadle / Edward Tatum / Joshua Lederberg (1958) · Severo Ochoa / Arthur Kornberg (1959) · Frank Burnet / Peter Medawar (1960) · Georg von Békésy (1961) · Francis Crick / James D. Watson / Maurice Wilkins (1962) · John Eccles / Alan Hodgkin / Andrew Huxley (1963) · Konrad Bloch / Feodor Lynen (1964) · François Jacob / André Lwoff / Jacques Monod (1965) · Francis Rous / Charles B. Huggins (1966) · Ragnar Granit / Haldan Hartline / George Wald (1967) · Robert W. Holley / Har Khorana / Marshall Nirenberg (1968) · Max Delbrück / Alfred Hershey / Salvador Luria (1969) · Bernard Katz / Ulf von Euler / Julius Axelrod (1970) · Earl Sutherland, Jr. (1971) · Gerald Edelman / Rodney Porter (1972) · Karl von Frisch / Konrad Lorenz / Nikolaas Tinbergen (1973) · Albert Claude / Christian de Duve / George Palade (1974) · David Baltimore / Renato Dulbecco / Howard Temin (1975) Complete roster · 1901–1925 · 1926–1950 · 1951–1975 · 1976–2000 · 2001–present

v • d • e National Medal of Science laureates   Behavioral and social science 1960s 1964: Roger Adams · Othmar H. Ammann · Theodosius Dobzhansky · Neal Elgar Miller 1980s 1986: Herbert A. Simon 1987: Anne Anastasi · George J. Stigler 1988: Milton Friedman 1990s 1990: Leonid Hurwicz · Patrick Suppes 1991: Robert W. Kates · George A. Miller 1992: Eleanor J. Gibson 1994: Robert K. Merton 1995: Roger N. Shepard 1996: Paul A. Samuelson 1997: William K. Estes 1998: William Julius Wilson 1999: Robert M. Solow 2000s 2000: Gary Becker 2001: George Bass 2003: R. Duncan Luce 2004: Kenneth Arrow 2005: Gordon H. Bower   Biological sciences 1960s 1963: C. B. van Niel 1964: Marshall W. Nirenberg 1965: Francis P. Rous · George G. Simpson · Donald D. Van Slyke 1966: Edward F. Knipling · Fritz Albert Lipmann · William C. Rose · Sewall Wright 1967: Kenneth S. Cole · Harry F. Harlow · Michael Heidelberger · Alfred H. Sturtevant 1968: Horace Barker · Bernard B. Brodie · Detlev W. Bronk · Jay Lush · Burrhus Frederic Skinner 1969: Robert Huebner · Ernst Mayr 1970s 1970: Barbara McClintock · Albert B. Sabin 1973: Daniel I. Arnon · Earl W. Sutherland, Jr. 1974: Britton Chance · Erwin Chargaff · James V. Neel · James Augustine Hannon 1975: Hallowell Davis · Paul Gyorgy · Sterling Brown Hendricks · Orville lvin Vogel 1976: Roger C.L. Guillemin · Keith Roberts Porter · Efraim Racker · E. O. Wilson 1979: Robert H. Burris · Elizabeth C. Crosby · Arthur Kornberg · Severo Ochoa · Earl Reece Stadtman · George Ledyard Stebbins · Paul Alfred Weiss 1980s 1981: Philip Handler 1982: Seymour Benzer · Glenn W. Burton · Mildred Cohn 1983: Howard L. Bachrach · Paul Berg · Wendell L. Roelofs · Berta Scharrer 1986: Stanley Cohen · Donald A. Henderson · Vernon B. Mountcastle · George Emil Palade · Joan A. Steitz 1987: Michael E. Debakey · Theodor O. Diener · Harry Eagle · Har Gobind Khorana · Rita Levi-Montalcini 1988: Michael S. Brown · Stanley N. Cohen · Joseph L. Goldstein · Maurice R. Hilleman · Eric R. Kandel · Rosalyn S. Yalow 1989: Katherine Esau · Viktor Hamburger · Philip Leder · Joshua Lederberg · Roger W. Sperry · Harland G. Wood 1990s 1990: Baruj Benacerraf · Herbert W. Boyer · Daniel E. Koshland, Jr. · Edward B. Lewis · David G. Nathan · E. Donnall Thomas 1991: Mary Ellen Avery · G. Evelyn Hutchinson · Elvin A. Kabat · Salvador Luria · Paul A. Marks · Folke K Skoog · Paul C. Zamecnik 1992: Maxine Singer · Howard M. Temin 1993: Daniel Nathans · Salome G. Waelsch 1994: Thomas Eisner · Elizabeth F. Neufeld 1995: Alexander Rich 1996: Ruth Patrick 1997: James D. Watson · Robert A. Weinberg 1998: Bruce Ames · Janet Rowley 1999: David Baltimore · Jared Diamond · Lynn Margulis 2000s 2000: Nancy C. Andreasen · Peter H. Raven · Carl Woese 2001: Francisco J. Ayala · Mario R. Capecchi · Ann M. Graybiel · Gene E. Likens · Victor A. McKusick · Harold Varmus 2002: James E. Darnell · Evelyn M. Witkin 2003: J. Michael Bishop · Solomon H. Snyder · Charles Yanofsky 2004: Norman E. Borlaug · Phillip A. Sharp · Thomas E. Starzl 2005: Anthony Fauci · Torsten N. Wiesel 2006: Rita R. Colwell · Nina Fedoroff · Lubert Stryer 2007: Robert J. Lefkowitz · Bert W. O'Malley   Chemistry 1980s 1982: F. Albert Cotton · Gilbert Stork 1983: Roald Hoffmann · George C. Pimentel · Richard N. Zare 1986: Harry B. Gray · Yuan Tseh Lee · Carl S. Marvel · Frank H. Westheimer 1987: William S. Johnson · Walter H. Stockmayer · Max Tishler 1988: William O. Baker · Konrad E. Bloch · Elias J. Corey 1989: Richard B. Bernstein · Melvin Calvin · Rudoph A. Marcus · Harden M. McConnell 1990s 1990: Elkan Blout · Karl Folkers · John D. Roberts 1991: Ronald Breslow · Gertrude B. Elion · Dudley R. Herschbach · Glenn T. Seaborg 1992: Howard E. Simmons, Jr. 1993: Donald J. Cram · Norman Hackerman 1994: George S. Hammond 1995: Thomas Cech · Isabella L. Karle 1996: Norman Davidson 1997: Darleane C. Hoffman · Harold S. Johnston 1998: John W. Cahn · George M. Whitesides 1999: Stuart A. Rice · John Ross · Susan Solomon 2000s 2000: John D. Baldeschwieler · Ralph F. Hirschmann 2001: Ernest R. Davidson · Gabor A. Somorjai 2002: John I. Brauman 2004: Stephen J. Lippard 2006: Marvin H. Caruthers · Peter B. Dervan 2007: Mostafa A. El-Sayed   Engineering sciences 1960s 1962: Theodore von Karman 1963: Vannevar Bush · John Robinson Pierce 1964: Charles S. Draper 1965: Hugh L. Dryden · Clarence L. Johnson · Warren K. Lewis 1966: Claude E. Shannon 1967: Edwin H. Land · Igor I. Sikorsky 1968: J. Presper Eckert · Nathan M. Newmark 1969: Jack St. Clair Kilby 1970s 1970: George E. Mueller 1973: Harold E. Edgerton · Richard T. Whitcomb 1974: Rudolf Kompfner · Ralph Brazelton Peck · Abel Wolman 1975: Manson Benedict · William Hayward Pickering · Frederick E. Terman · Wernher von Braun 1976: Morris Cohen · Peter C. Goldmark · Erwin Wilhelm Müller 1979: Emmett N. Leith · Raymond D. Mindlin · Robert N. Noyce · Earl R. Parker · Simon Ramo 1980s 1982: Edward H. Heinemann · Donald L. Katz 1983: William R. Hewlett · George M. Low · John G. Trump 1986: Hans Wolfgang Liepmann · T. Y. Lin · Bernard M. Oliver 1987: Robert B. Bird · H. Bolton Seed · Ernst Weber 1988: Daniel C. Drucker · Willis M. Hawkins · George W. Housner 1989: Harry George Drickamer · Herbert E. Grier 1990s 1990: Mildred S. Dresselhaus · Nick Holonyak Jr. 1991: George Heilmeier · Luna B. Leopold · H. Guyford Stever 1992: Calvin F. Quate · John Roy Whinnery 1993: Alfred Y. Cho 1994: Ray W. Clough 1995: Hermann A. Haus 1996: James L. Flanagan · C. Kumar N. Patel 1998: Eli Ruckenstein 1999: Kenneth N. Stevens 2000s 2000: Yuan-Cheng B. Fung 2001: Andreas Acrivos 2002: Leo Beranek 2003: John M. Prausnitz 2004: Edwin N. Lightfoot 2005: Jan D. Achenbach · Tobin J. Marks 2006: Robert S. Langer 2007: David J. Wineland   Mathematical, statistical, and computer sciences 1960s 1963: Norbert Wiener 1964: Solomon Lefschetz · H. Marston Morse 1965: Oscar Zariski 1966: John Milnor 1967: Paul Cohen 1968: Jerzy Neyman 1969: William Feller 1970s 1970: Richard Brauer 1973: John Tukey 1974: Kurt Gödel 1975: John W. Backus · Shiing-Shen Chern · George Dantzig 1976: Kurt Otto Friedrichs · Hassler Whitney 1979: Joseph Leo Doob · Donald E. Knuth 1980s 1982: Marshall Harvey Stone 1983: Herman Goldstine · Isadore Singer 1986: Peter Lax · Antoni Zygmund 1987: Raoul Bott · Michael Freedman 1988: Ralph E. Gomory · Joseph B. Keller 1989: Samuel Karlin · Saunders MacLane · Donald C. Spencer 1990s 1990: George F. Carrier · Stephen Cole Kleene · John McCarthy 1991: Alberto Calderón 1992: Allen Newell 1993: Martin David Kruskal 1994: John Cocke 1995: Louis Nirenberg 1996: Richard Karp · Stephen Smale 1997: Shing-Tung Yau 1998: Cathleen Synge Morawetz 1999: Felix Browder · Ronald R. Coifman 2000s 2000: John Griggs Thompson · Karen K. Uhlenbeck 2001: Calyampudi R. Rao · Elias M. Stein 2002: James G. Glimm 2003: Carl R. de Boor 2004: Dennis P. Sullivan 2005: Bradley Efron 2006: Hyman Bass 2007: Leonard Kleinrock · Andrew J. Viterbi   Physical sciences 1960s 1963: Luis W. Alvarez 1964: Julian Schwinger · Harold Clayton Urey · Robert Burns Woodward 1965: John Bardeen · Peter Debye · Leon M. Lederman · William Rubey 1966: Jacob Bjerknes · Subrahmanyan Chandrasekhar · Henry Eyring · John H. Van Vleck · Vladimir K. Zworykin 1967: Jesse Beams · Francis Birch · Gregory Breit · Louis Hammett · George Kistiakowsky 1968: Paul Bartlett · Herbert Friedman · Lars Onsager · Eugene Wigner 1969: Herbert C. Brown · Wolfgang Panofsky 1970s 1970: Robert H. Dicke · Allan R. Sandage · John C. Slater · John A. Wheeler · Saul Winstein 1973: Carl Djerassi · Maurice Ewing · Arie Jan Haagen-Smit · Vladimir Haensel · Frederick Seitz · Robert Rathbun Wilson 1974: Nicolaas Bloembergen · Paul Flory · William Alfred Fowler · Linus Carl Pauling · Kenneth Sanborn Pitzer 1975: Hans A. Bethe · Joseph Hirschfelder · Lewis Sarett · E. Bright Wilson · Chien-Shiung Wu 1976: Samuel Goudsmit · Herbert S. Gutowsky · Frederick Rossini · Verner Suomi · Henry Taube · George Uhlenbeck 1979: Richard P. Feynman · Herman Mark · Edward M. Purcell · John Sinfelt · Lyman Spitzer · Victor F. Weisskopf 1980s 1982: Philip W. Anderson · Yoichiro Nambu · Edward Teller · Charles H. Townes 1983: E. Margaret Burbidge · Maurice Goldhaber · Helmut Landsberg · Walter Munk · Frederick Reines · Bruno B. Rossi · J. Robert Schrieffer 1986: Solomon Buchsbaum · Horace Crane · Herman Feshbach · Robert Hofstadter · Chen Ning Yang 1987: Philip Abelson · Walter Elsasser · Paul C. Lauterbur · George Pake · James A. Van Allen 1988: D. Allan Bromley · Paul Ching-Wu Chu · Walter Kohn · Norman F. Ramsey · Jack Steinberger 1989: Arnold O. Beckman · Eugene Parker · Robert Sharp · Henry Stommel 1990s 1990: Allan M. Cormack · Edwin M. McMillan · Robert Pound · Roger Revelle 1991: Arthur L. Schawlow · Ed Stone · Steven Weinberg 1992: Eugene M. Shoemaker 1993: Val Fitch · Vera Rubin 1994: Albert Overhauser · Frank Press 1995: Hans Dehmelt · Peter Goldreich 1996: Wallace S. Broecker 1997: Marshall Rosenbluth · Martin Schwarzschild · George Wetherill 1998: Don L. Anderson · John N. Bahcall 1999: James Cronin · Leo Kadanoff 2000s 2000: Willis E. Lamb · Jeremiah P. Ostriker · Gilbert F. White 2001: Marvin L. Cohen · Raymond Davis Jr. · Charles Keeling 2002: Richard Garwin · W. Jason Morgan · Edward Witten 2003: G. Brent Dalrymple · Riccardo Giacconi 2004: Robert N. Clayton 2005: Ralph A. Alpher · Lonnie Thompson 2006: Daniel Kleppner 2007: Fay Ajzenberg-Selove · Charles P. Slichter

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