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Meloxicam

 
Drug Info: Meloxicam

Brand names: Mobic®

Chemical formula:



Meloxicam tablets

What are meloxicam tablets?

MELOXICAM (Mobic®) is used for osteoarthritis or rheumatoid arthritis to reduce pain and inflammation. Meloxicam has also been used to treat mild to moderate pain due to other conditions. Generic meloxicam is available.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
• asthma, especially aspirin sensitive asthma
• bleeding problems or taking medicines that make you bleed more easily such as anticoagulants ('blood thinners')
• cigarette smoker
• coronary artery bypass graft (CABG) surgery within the past 2 weeks
• dental disease
• diabetes
• drink more than 3 alcohol-containing beverages a day
• heart disease or circulation problems such as heart failure or leg edema (fluid retention)
• high blood pressure
• kidney disease
• liver disease
• stomach or duodenal ulcers
• systemic lupus erythematosus
• ulcerative colitis
• an unusual or allergic reaction to aspirin, other salicylates, meloxicam, piroxicam, other NSAIDs, other medicines, foods, dyes or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I take this medicine?

Take meloxicam tablets by mouth. Follow the directions on the prescription label. Swallow tablets whole with a full glass of water; take tablets in an upright or sitting position. Taking a sip of water first, before taking the tablets, may help you swallow them. If possible take bedtime doses at least 10 minutes before lying down. If meloxicam upsets your stomach, take it with food or milk. Take your doses at regular intervals. Do not take your medicine more often than directed.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

Elderly patients over 65 years old may have a stronger reaction to this medicine and need smaller doses.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What drug(s) may interact with meloxicam?

• alcohol
alendronate
• aspirin and aspirin-like medicines
cidofovir
cyclosporine
• drospirenone; ethinyl estradiol (Yasmin®)
entecavir
• herbal products that contain feverfew, garlic, ginger, or ginkgo biloba
lithium
• medicines for high blood pressure
• medicines that affect platelets
• medicines that treat or prevent blood clots such as warfarin and other 'blood thinners'
methotrexate
• other antiinflammatory drugs (such as ibuprofen or prednisone)
pemetrexed
• water pills (diuretics)

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What should I watch for while taking meloxicam?

Let your prescriber or health care professional know if your pain continues; do not take with other pain-killers without advice. If you get flu-like symptoms (fever, chills, muscle aches and pains), call your prescriber or health care professional; do not treat yourself.

To reduce unpleasant effects on your stomach, take meloxicam with a full glass of water and never just before lying down. You may also take this medicine with food to decrease stomach upset. If you notice black, tarry stools or experience severe stomach pain and/or vomit blood or what looks like coffee grounds, notify your health care prescriber immediately.

Meloxicam cannot take the place of aspirin for the prevention of heart attack or stroke. If you are taking medicines that affect the clotting of your blood, such as aspirin or blood thinners such as Coumadin®, talk to your health care provider or prescriber before taking this medicine. If you are currently taking aspirin for this purpose, you should not discontinue taking aspirin without checking with your prescriber or health care professional.

Do not smoke cigarettes or drink alcohol; these increase irritation to your stomach and can make it more susceptible to damage from meloxicam.

It is especially important not to use meloxicam during the last 3 months of pregnancy unless specifically directed to do so by your health care provider. Meloxicam may cause problems in the unborn child or complications during delivery.

Avoid taking other prescription or over-the-counter non steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil®) or naproxen (Aleve®) while taking meloxicam. Side effects including stomach upset, heartburn, nausea, vomiting, or serious side effects such as ulcers are more likely if meloxicam is given with other NSAIDs. Many non-prescription products contain NSAIDs; closely read labels before taking any medicines with meloxicam.

What side effects may I notice from taking meloxicam?

Long-term, continuous use may increase the risk of heart attack or stroke. Patients should seek immediate emergency help in the case of a serious allergic reaction.

Side effects that you should report to your prescriber or health care professional as soon as possible:
• signs of bleeding - bruising, pinpoint red spots on the skin, black tarry stools, blood in the urine, unusual tiredness or weakness, vomiting blood or vomit that looks like coffee grounds
• signs of an allergic reaction - difficulty breathing or wheezing, skin rash, redness, blistering or peeling skin, hives, or itching, swelling of eyelids, throat, lips
• blurred vision
• chest pain
• decrease in the amount of urine passed
• difficulty swallowing, severe heartburn or burning, pain in throat
• nausea or vomiting
• slurred speech or weakness on one side of the body
• stomach pain or cramps
• swelling of feet or ankles
• unexplained weight gain or edema
• yellowing of eyes or skin

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• constipation or diarrhea
• difficulty swallowing
• dizziness
• gas or heartburn
• minor upset stomach

Where can I keep my medicine?

Keep out of the reach of children in a container that small children cannot open.

Store at room temperature 15—30 degrees C (59—86 degrees F). Protect from moisture. Keep container tightly closed. Throw away any unused medicine after the expiration date.

Last updated: 7/1/2002

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

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Veterinary Dictionary: meloxicam
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A nonsteroidal anti-inflammatory drug used in dogs for management of pain.

Wikipedia: Meloxicam
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Meloxicam
Systematic (IUPAC) name
(8E)-8-[hydroxy-[(5-methyl-1,3-thiazol-2-yl)amino]
methylidene]-9-methyl-10,10-dioxo-10λ6-thia-9-
azabicyclo[4.4.0]deca-1,3,5-trien-7-one
Identifiers
CAS number 71125-38-7
ATC code M01AC06
PubChem 5281106
DrugBank APRD00529
ChemSpider 10442740
Chemical data
Formula C14H13N3O4S2 
Mol. mass 351.403 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability 89%
Protein binding 99.4%
Metabolism Hepatic (CYP2C9 and 3A4-mediated)
Half life 15 to 20 hours
Excretion Urine and faeces equally
Therapeutic considerations
Pregnancy cat.

C(US) D in third trimester

Legal status

POM(UK) -only(US)

Routes Oral
 Yes check.svgY(what is this?)  (verify)

Meloxicam is a nonsteroidal anti-inflammatory drug of the oxicam class, used to relieve the symptoms of arthritis, primary dysmenorrhea, fever; and as an analgesic, especially where there is an inflammatory component. It has been developed by Boehringer-Ingelheim. It is closely related to piroxicam.

In Europe it is marketed under the brand names Movalis, Melox, and Recoxa. In the Philippines it is generally marketed as the brand name Moxen. In the UK, U.S., Middle East, Thailand and Australia it is generally marketed under the brand name Mobic, in Germany as Mobec, and in Canada as Mobicox. In Latin America, the drug is marketed as Tenaron, Ilacox or Melocam. A veterinary formulation of the drug is marketed in the U.S. and in France as Metacam by the Vetmedica division of Boehringer-Ingelheim.

Box and strip of Meloxicam (Mobic) 7.5mg

Contents

Mechanism of action

Meloxicam inhibits cyclooxygenase (COX), the enzyme responsible for converting arachidonic acid into prostaglandin H2—the first step in the synthesis of prostaglandins, which are mediators of inflammation. Meloxicam has been shown, especially at its low therapeutic dose, selectively to inhibit COX-2 over COX-1.

A primary advantage of the oxicam family of drugs is their long half-life which permits once-day dosing.

Adverse effects

Meloxicam use can result in gastrointestinal toxicity and bleeding, tinnitus, headache, rash, very dark or black stool (sign of intestinal bleeding). The risk of adverse side effects is lower than with piroxicam, diclofenac, or naproxen. Although meloxicam does inhibit thromboxane A, it does not appear to do so at levels that would interfere with platelet function.

In rare situations, it could cause serious liver disease. If there is a sensation of fatigue and/or liver pain, intake must be ceased.

Two Meloxicam pills, showing either side

Approval status

Meloxicam is licensed in Europe for treatment of rheumatoid arthritis, for short term use in osteoarthritis and for ankylosing spondylitis. As of 2004 it has been approved for use in treating osteoarthritis in the United States of America and is marketed in the under the name of Metacam by Boehringer Ingelheim Vetmedica.

Veterinary use

Under the brand name Metacam, meloxicam is also used in the veterinary field, most commonly in dogs and cattle, but also in other animals such as cats and exotics; in the U.S. is indicated for management of pain and inflammation associated with osteoarthritis in dogs (FDA.gov), and in Europe, where the product has been available since the early 1990s, it is also prescribed and licensed for other anti-inflammatory benefits including relief from both acute and chronic pain in dogs and cats. Side effects in animals are similar to those found in humans; the principal side effect is gastrointestinal irritation (vomiting, diarrhea and ulceration). Rarer but important side effects include liver and kidney toxicity.

For many years, both injectable and oral (liquid and tablet) formulations of meloxicam have been licensed for use in dogs, and injectable ones for use in cats. In June 2007, a new oral version of Metacam was licensed in Europe for the long-term relief of pain in cats. As of June 2008, Meloxicam is registered for long term use in cats in Australia, New Zealand, and throughout Europe. 'Metacam oral suspension 1.5 is not approved or recommended (according to the manufacture insert) for use in cats in the U.S.

Generic form of Metacam

Metacam is marketed in a generic form in Canada under the trade name Petcam.

References


 
 

 

Copyrights:

Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved.  Read more
Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved.  Read more
Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Meloxicam" Read more