A purified preparation of gonadotropins extracted from the urine of postmenopausal women, containing follicle-stimulating hormone (FSH) and luteinizing hormone (LH); used in the treatment of human infertility.
Menotropin
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Menotropin
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| CAS number | 61489-71-2 |
| ATC code | G03GA02 |
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Menotropin is an active substance for the treatment of fertility disturbances. It is extracted from human urine from menopausal women [1] and contains the two gonadotropin hormones LH and FSH.
Menotropin medications include Menopur, Menogon, Repronex, Pergonal and HMG Massone.[2] HMG (Human Menopausal Gonadotropin)[citation needed] is used for stimulating hormones by triggering FSH and LH production in the body. This drug was originally designed for use in women where it stimulates the ovaries to produce multiple follicles, thus making them more fertile.
Human urinary-derived menotropin preparations are exposed to the theoretical risk of infection from menopausal donors of urine. Nevertheless, the failure to demonstrate irrefutably infectivity following intracerebral inoculation with urine from TSE-infected hosts suggests that the risk associated with products derived from urine is merely theoretical[3].
The Practice Committee of the American Society for Reproductive Medicine reported[4]: “Compared with earlier crude animal extracts, modern highly purified urinary and recombinant gonadotropin products have clearly superior quality, specific activity, and performance. There are no confirmed differences in safety, purity, or clinical efficacy among the various available urinary or recombinant gonadotropin products.”
References
- ^ MeSH Menotropins
- ^ Fuller, Matthew A.; Martha Sajatovic (2003). Drug Information Handbook for Psychiatry (4 ed.). Lexi-Comp, Inc.. p. 711. ISBN 1591950643.
- ^ Reichl H, Balen A, Jansen CA (October 2002). "Prion transmission in blood and urine: what are the implications for recombinant and urinary-derived gonadotrophins?". Human reproduction (Oxford, England) 17 (10): 2501–8. PMID 12351519. http://humrep.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=12351519.
- ^ Gonadotropin preparations: past, present, and future perspectives. The Practice Committee of the American Society for Reproductive Medicine, Birmingham, Alabama Fertility and Sterility Vol. 90, Suppl 3, November 2008 http://www.ncbi.nlm.nih.gov/pubmed/19007609
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 | Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved. Read more |
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