Results for methohexital
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Drug Info:

Methohexital

Brand names: Brevital®

Chemical formula:



Methohexital injection

What is methohexital injection?

METHOHEXITAL (Brevital®) helps to produce relaxation, deep sleep or loss of consciousness before and during surgery. It does not relieve pain. Methohexital may be supplemented by other medicines to produce the type of anesthesia (loss of sensation) required. Generic methohexital injections are not yet available.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
• Addison's disease
• a history of seizures or convulsions
• an alcohol or drug abuse problem
• anemia, or low blood iron
• asthma or other breathing difficulties, such as sleep apnea; lung disease
• attempted suicide
• heart or vein disease
• high or low blood pressure
• liver or kidney disease
• low blood pressure
• mental depression or other mental health issues; thoughts of suicide
• neuromuscular disease, such as muscular dystrophy or myasthenia gravis
• porphyria
• thyroid problems
• an unusual or allergic reaction to thiopental, other barbiturates, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine?

Methohexital is for injection into a vein. It is given by a trained health-care professional in a hospital or clinic setting.

What if I miss a dose?

This does not apply.

What drug(s) may interact with methohexital?

• alcohol
• herbal products, including St. John's wort
• insulin
• magnesium sulfate
• medicines for anxiety and sleeping problems, such as diazepam or temazepam
• medicines for depression
• medicines for colds, breathing difficulties, or weight loss
• medicines for high blood pressure
• medicines for mental problems and psychotic disturbances
• medicines for pain

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What should I watch for while taking methohexital?

The effects of methohexital generally wear off in a few hours. However, methohexital can affect your ability to drive or do anything that needs mental alertness. Do not attempt to drive yourself home if you have received methohexital for minor outpatient surgery. You may feel dizzy and lightheaded. To reduce the risk of dizzy or fainting spells, do not sit up or stand up quickly, especially if you are an older patient. Alcohol can make you more drowsy or dizzy, avoid alcoholic drinks for at least 24 hours after you receive methohexital.

What side effects may I notice from receiving methohexital?

Side effects that you should report to your prescriber or health care professional as soon as possible:
• coughing or hiccups
• difficulty breathing, wheezing
• dizziness or lightheadedness
• irregular heartbeats (palpitations)
• muscle twitching
• numbness or tingling in the hands or feet
• pain or swelling at the injection site
• seizures (convulsions)
• skin rash, itching (hives)
• swelling of the face, lips or eyelids

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• anxiety, confusion, hallucinations
• drowsiness
• headache
• nausea, vomiting
• shivering or trembling

Where can I keep my medicine?

This does not apply.

Last updated: 7/1/2002

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

 
 
Wikipedia: methohexital
Methohexital2.png
Methohexital
Systematic (IUPAC) name
5-hex-3-yn-2-yl-1- methyl-5-prop-2-enyl-1, 3-diazinane-2,4,6-trione
Identifiers
CAS number 151-83-7
ATC code N01AF01 N05CA15
PubChem 9034
DrugBank APRD00058
Chemical data
Formula C14H18N2O3 
Mol. mass 262.304
Pharmacokinetic data
Bioavailability I.V. ~100%
Rectal ~17%
Metabolism Hepatic
Half life 5.6 ± 2.7 minutes
Excretion  ?
Therapeutic considerations
Pregnancy cat.

B (USA)

Legal status

?

Routes Intravenous, rectal

Methohexital (marketed under the brand name Brevital) is a drug which is a barbiturate derivative. It is classified as short-acting, and has a rapid onset of action. It is similar in its effects to sodium thiopental, a drug with which it competed in the market for anaesthetics.

Pharmacology

Methohexital binds to a distinct site which is associated with Cl ionophores at GABAA receptors. This increases the length of time which the Cl ionopores are open, thus causing an inhibitory effect.

Metabolism of methohexital is primarily hepatic (i.e. taking place in the liver), via demethylation and oxidation. Side-chain oxidation is the primary means of metabolism involved in the termination of the drug's biological activity.

Protein binding is approximately 73% for methohexital.

Indications

Methohexital is primarily used to induce anesthesia, and is generally provided as a sodium salt (i.e. methohexital sodium). It is only used in hospital or ambulatory care (i.e. in an ambulance) settings, under strict supervision. It has been commonly used to induce deep sedation, "twilight sleep" or general anesthesia for oral surgery and dentistry. It is also used to induce anesthesia prior to ECT(electroconvulsive therapy).

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Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved.  Read more
Wikipedia. This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Methohexital" Read more

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