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Michael Bishop

 
Britannica Concise Encyclopedia: John Michael Bishop

(born Feb. 22, 1936, York, Pa., U.S.) U.S. virologist. He graduated from Harvard Medical School. In 1970 he and Harold Varmus tested the theory that healthy body cells contain oncogenes (cancer-causing genes). Further research showed that such genes can cause cancer even without viral involvement. By 1989, the year Bishop and Varmus shared a Nobel Prize for their research, scientists had identified more than 40 oncogenes in animals.

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Scientist: John Michael Bishop
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American microbiologist (1936–)

Bishop attended Gettysburg College and studied medicine at Harvard University. In 1962 he secured an internship at Massachusetts General Hospital in Boston, and in 1964 he moved to the National Institutes of Health, Washington DC, as research associate in virology, later becoming senior investigator (1966) and assistant professor (1968). He was appointed professor of microbiology and immunology at the University of California Medical Center, San Francisco, in 1972, and in 1981 he became director of the G. W. Hooper Research Foundation.

Bishop, working in collaboration with Harold Varmus, demonstrated for the first time that cancer-causing genes (oncogenes) carried by certain viruses are derived from normal genes present in the cells of their host, known as proto-oncogenes. This work by the team at the University of California, published in 1976, led to the discovery of many more such cellular genes, and represented a major advance in cancer research. In recognition of this, Bishop and Varmus were jointly awarded the 1989 Nobel Prize for physiology or medicine.

 
Columbia Encyclopedia: John Michael Bishop
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Bishop, John Michael, 1936-, American biologist, b. York, Penn., M.D. Harvard, 1962. He worked (1964-68) as a researcher at the National Institutes of Health in Bethesda, Md., before joining the faculty of the Univ. of California at San Francisco, where he has been chancellor since 1998. Bishop and his colleague Harold E. Varmus discovered the cellular origin of retroviral oncogenes, for which they were awarded the 1989 Nobel Prize in Physiology or Medicine.

Bibliography

See his memoir, How to Win the Nobel Prize: An Unexpected Life in Science (2003).

Medical Dictionary: Bish·op
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(bĭsh'əp), J. Michael Born 1936.

American microbiologist. He shared a 1989 Nobel Prize for discovering a sequence of genes that can cause cancer when mutated.

Wikipedia: Michael Bishop
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Columbia Encyclopedia. The Columbia Electronic Encyclopedia, Sixth Edition Copyright © 2003, Columbia University Press. Licensed from Columbia University Press. All rights reserved. www.cc.columbia.edu/cu/cup/ Read more
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