Yes, this is a safe combination, with a caveat. Most individuals are heavily sedated for the initiation of mirtazapine treatment. This effect usually disappears as the patient adjusts to the mirtazapine. If you still find a powerful sedative effect from mirtazapine, you should be advised to keep the dose of codeine low. If you are adjusted to the sedative effect, you can safely take whatever dose of codeine your doctor advised.

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I am currently on 600 mg of Seroquel and 30 mg of mirtazapine. so far so good and am doing so under the advisement of a Psychiatrist.

Higher doses of mirtazapine need to be done only witha dr's consent due to the mirtazapine effecting manic episodes.