Missense

A missense protein is a protein translated due to a change in a single amino acid.

Both a silent and missense mutation is a change in one nucleotide. However, a silent mutation still codes for the same amino acid, but a missense mutation codes for a different amino acid. This means that a silent mutation will have no affect on the resulting protein, but a missense mutation will.

Still, it is not guaranteed that a a missense mutation will result in a disfunction of created protein, as long as it is not occurring in the activation site.

Missense mutation

Both nonsense and missense mutations are point mutations - meaning a single base has been substituted.

The difference between the two is that a missense mutation results in an amino acid being replaced with a different amino acid, whereas a nonsense mutation results in a premature stop codon.