This drug should not be taken with the following medication because very serious interactions may occur: a certain weight loss drug (sibutramine).

Do not take this medication if you are taking MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine) or have used MAO inhibitors in the past 2 weeks. In some cases a serious, possibly fatal, drug interaction may occur.

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting sumatriptan.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: certain types of antidepressants (e.g., SSRIs such as fluoxetine/paroxetine/sertraline, NSRIs such as venlafaxine).

If you also take any ergotamine medication (e.g., dihydroergotamine or methysergide) or any other "triptan" drugs (e.g., zolmitriptan, rizatriptan), you will need to separate your sumatriptan dose from your dose of these other medications in order to lessen the chance of serious side effects. Ask your doctor how long you should wait between your doses of these drugs.

An MAOI is a Mono-amine Oxidase Inhibitor which is a type antidepressant. They are used to treat atypical depression, to help people stop smoking, treat agoraphobia and social anxiety. These drugs include Isocarboxazid (Marplan), Moclobemide (Aurorix, Manerix, Moclodura), Phenelzine (Nardil), Tranylcypromine (Parnate contents 5 mg, Jatrosom contents 10 mg), Selegiline (Selegiline, Eldepryl), Emsam, Nialamide, Iproniazid (Marsilid, Iprozid, Ipronid, Rivivol, Propilniazida), Iproclozide, and Toloxatone.

Nausea, vomiting constipation lightheadedness, dizziness, drowsiness headache, or vision changes may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell you doctor immediately if any of these serious side effects occur: mental/mood changes. Tell your doctor immediately if this highly unlikely but very serious side effect occurs: change in the color of urine. If you do not have liver problems, the adult maximum dose of acetaminophen is 4 grams per day (4000 milligrams). If you take more than the maximum daily amount, it may cause serious (possibly fatal) liver disease. Propoxyphene may also rarely cause liver disease. Seek immediate medical attention if you have any of the following symptoms of liver damage: severe nausea/vomiting, stomach/abdominal pain, yellowing eyes or skin, dark urine, extreme fatigue. If you have liver problems, consult your doctor or pharmacist for a safe dosage of this medication. A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above contact your doctor or pharmacist. In the US - Call your doctor for medical advice about the side effects. You may report side effects to FDA at 1-800-FDA-1088.

Drug Interaction caution: Naltrexone, Blood thinners (Warfarin), carbamazepine, cimetidine, MAO inhibitors (e.g. furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine), other pain medications, tricyclic antidepressants (e.g., doxepin). Drugs that cause drowsiness such as: anti-anxiety drugs (e.g. diazepam), antidepressants (e.g. amitriptyline), antihistamines that cause drowsiness (e.g., diphenyhdramine, anti-seizure drugs (e.g., peneobarbital, medicine for sleep (e.g., sedatives) muscle relaxants, psychiatric medicines (e.g., phenothiazines such as chlorpromazine), tranquilizers. Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain ingredients that cause drowsiness.