Congenital myasthenic syndromes are a group of related disorders caused by inherited defects in the acetylcholine receptor.

Lambert-Eaton myasthenic syndrome is an autoimmune disease that causes muscle weakness and easy fatigability, particularly in the pelvic muscles and thighs.

Family history of Lambert-Eaton myasthenic syndrome is a known risk factor for development of the disease, as is a personal history of smoking

Patients who develop Lambert-Eaton myasthenic syndrome should be thoroughly screened for the presence of a previously undetected cancer

Patients with Lambert-Eaton myasthenic syndrome should be examined and then treated by both a neurologist and an appropriate cancer specialist (oncologist).