caused by a mutation in a gene called myelin protein zero (MPZ) located on chromosome 1.

Nicotine stimulates CREB phosphorylation which regulates the expression of myelin basic protein and myelin oligodendrocyte glycoprotein.

Myelin is the material that surrounds and protects the spinal cord, and it helps conduct information signals up and down the cord. Myelin is rich in protein.

I think your confused. The fact is that there is an elevated level of myelin basic protein in the cerebrospinal fluid. This is common to people how have multiple sclerosis.

I think the real question is :WHY is there an elevated level of myelin basic protein in the cerebrospinal fluid

hope this helps:)

Myelin is composed of about 80% lipid and about 20% protein. Some of the proteins that make up myelin are myelin basic protein (MBP),myelin oligodendrocyte glycoprotein (MOG), and proteolipid protein (PLP). Myelin is made up primarily of a glycolipid calledgalactocerebroside. The intertwining of the hydrocarbon chains of sphingomyelin serve to strengthen the myelin sheath.

There are quite a few disease (multiple sclerosis, optic neuritis, transverse myelitis..) involved in the destruction of the axon myelin sheath also known as myelin sheath.


http://en.wikipedia.org/wiki/Myelin