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Basically it binds with oxygen to form oxymyoglobin. when muscles are excercising excessively oxymyoglobin splits and the oxygen is released into the blood to fuel the muscles by assisting in the production of ATP.

The main function of myoglobin is to carry oxygen to muscle tissues that have been damaged. Myoglobin is only found in a muscle injury.

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Basically it binds with oxygen to form oxymyoglobin. when muscles are excercising excessively oxymyoglobin splits and the oxygen is released into the blood to fuel the muscles by assisting in the production of ATP.

The main function of myoglobin is to carry oxygen to muscle tissues that have been damaged. Myoglobin is only found in a muscle injury.

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These are all screening test, but not confirmation test. Red, cloudy urine means hematuria (blood in the urine) Red, clear urine means hemaglobinuria (hemaglobin in the urine. Dark reddish brown cola-colored urine means Myoglobinuria (myoglobin in the urine) Beer-brown-colored urine means indicative of bilirubin Dark red like port wine-colored urine means porphyrins (iron pigment). Very turbid urine means pyuria (Abnormal numbers of white blood cells in the urine) Orange Urine means the patient consume a lot of beta-carotene. Black to Dark brown urine means Alkaptonuria (melanin or homogentisic acid in the urine) Huge amount of urine means polyuria and may have type I/II diabetes High bilirubin levels in urine means hepatitis/jaundice High urobilinogen level in urine means excessive destruction of Red blood cells or patient have infectious mononucleosis. Low / No Urobilinogen and High Bilirubin in urine with high levels of bilirubin in the blood means Obstruction of Bile ducts/Obstructive jaundice Urine positive for Ketones means diabetic ketoacidosis, the patient is diabetic or having a crash diet. High glucose level in urine means lack of control of the diabetes High glucose level and normal blood sugar level means lowered renal threshold. Marked High Protein level in the urine means Nephrotic syndrome, Renal vein thrombosis, Amyloid disease, Lupus erythematosus. (4 gms/day) High protein level and heated at 100 C becomes normal/low protein level means multiple myeloma/macroglobulinemia. There are more informations if you bought the urinalysis book.

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Definition

McArdle syndrome is the inability to break down glycogen. Glycogen is an important source of energy that is stored in muscle tissue.

Alternative Names

Glycogen storage disease type V (GSDV); Myophosphorylase deficiency; Muscle glycogen phosphorylase deficiency; PGYM deficiency

Causes, incidence, and risk factors

McArdle syndrome is caused by a defect in a gene that makes an enzyme called glycogen phosphorylase. As a result, the body cannot break down glycogen in the muscles.

The disease is an autosomal recessive genetic disorder. This means that you must get a copy of the non-working gene from both parents. A person who gets a non-working gene from only one parent usually does not develop this syndrome. A family history of McArdle syndrome increases the risk.

The disease usually starts when a person is in their 20s or 30s, but there is a very rare form that begins in infants.

Symptoms
  • Burgundy-colored urine (myoglobinuria)
  • Fatigue
  • Exercise intolerance, poor stamina
  • Muscle cramps
  • Muscle pain
  • Muscle stiffness
  • Muscle weakness
Signs and tests

The following tests may be performed:

Treatment

There is no specific treatment, but you can manage the symptoms by improving exercise tolerance and controlling physical activity. Avoid excessive or intense exercise.

Dietary management should include having a supply of glucose (candy, for example) on hand if you need to replace energy.

Avoid general anesthesia.

Support Groups

For additional information and resources, visit the Association for Glycogen Storage Disease at www.agsdus.org.

Expectations (prognosis)

People with McArdle syndrome can live a normal life by managing their physical activity.

Complications

Exercise may produce muscle pain, or even a breakdown of skeletal muscle (rhabdomyolysis). This condition is associated with burgundy-colored urine and a risk for kidney failure, if it is severe.

Calling your health care provider

Contact your health care provider if you have repeated episodes of sore or cramped muscles after exercise, especially if you also have burgundy or pink urine.

Consider genetic counseling if you have a family history of McArdle disease.

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