Nanogram per liter (ng/L) and milligram per liter (mg/L) are both units of measurement used to express the concentration of a substance in a liquid. The main difference is in their scale: nanogram per liter is a smaller unit of measurement than milligram per liter. 1 milligram (mg) is equal to 1,000,000 nanograms (ng), so if a substance is measured in ng/L, it would be a much smaller concentration compared to if it were measured in mg/L.