Nonsense

nonsense mutation

nonsense mutation, missense mutation, frameshift muation, deletion or addition mutation

Both nonsense and missense mutations are point mutations - meaning a single base has been substituted.

The difference between the two is that a missense mutation results in an amino acid being replaced with a different amino acid, whereas a nonsense mutation results in a premature stop codon.

The type of mutation that stops the translation of a protein is a nonsense mutation. This occurs when a base substitution (point mutation) results in a STOP codon and thus stops translation of the sequence into a protein.