A person with periodic paralysis experiences sudden onset of weakness, which gradually subsides, only to return again later.

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Periodic paralysis disorders are genetic disorders that affect muscle strength. There are two major forms, hypokalemic and hyperkalemic, each caused by defects in different genes.

Periodic paralysis (PP) is the name for several rare, inherited muscle disorders marked by temporary weakness, especially following rest, sleep, or exercise.

With hypokalemic periodic paralysis an attack of weakness can be induced by administering glucose and insulin with exercise. These tests are potentially hazardous and require careful monitoring.