Nobis Sancti Spiritus is the start of a verse from Horae Spiritus Sancti ("Hours of the Holy Spirit"), a medieval monastic office.
The full line of text in which these words appear is Nobis Sancti Spiritus gratia sit data, which is "May the grace of the Holy Spirit be given to us." (Nobis is "to us" and Sancti Spiritus is "of the Holy Spirit".)