(medicine) A blue or brownish-blue discoloration of cartilage and connective tissue, especially around joints, caused by melanotic pigment.
Ochronosis
| Sci-Tech Dictionary: ochronosis |
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| Medical Dictionary: o·chro·no·sis |
n.
A condition observed in certain patients with alkaptonuria and marked by pigmentation of cartilage and sometimes of other tissues.
o'chro·not'ic (-nŏt'ĭk) adj.| Veterinary Dictionary: ochronosis |
A yellow, brown or chocolate discoloration of cartilage, tendon sheaths and ligaments but not bone. Caused by deposit of alkapton bodies as the result of a metabolic disorder. Affected parts must be condemned as not suitable for human consumption.
- ocular o. — brown or gray discoloration of the sclera, sometimes involving also the conjunctivae and eyelids.
| WordNet: ochronosis |
Note: click on a word meaning below to see its connections and related words.
The noun has one meaning:
Meaning #1:
an accumulation of dark pigment in cartilage and other connective tissue; usually a symptom of alkaptonuria or phenol poisoning
| Wikipedia: Ochronosis |
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This article needs additional citations for verification. Please help improve this article by adding reliable references. Unsourced material may be challenged and removed. (December 2007) |
| Ochronosis | |
| Classification and external resources | |
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|---|---|
| Homogentisic acid | |
| ICD-10 | E70.2 |
| ICD-9 | 270.2 |
| DiseasesDB | 409 |
| eMedicine | derm/476 |
| MeSH | D009794 |
Ochronosis, often called alkaptonuric ochronosis,[1] is an autosomal recessive metabolic disorder that causes an excess of homogentisic acid, resulting in adverse pigmentation, calcification, and inflammation of cartilagenous and related tissue throughout the body.[2]:542
The disorder is a result of incomplete metabolism of homogentisic acid, tyrosine and phenylalanine.
The face, skeletal system, cardiovascular system,[3] respiratory system, urinary system and to a lesser degree, the skin, are affected by this disease.
Contents |
Symptoms
Pigmented cartilage may appear blue due to a light scattering phenomenon (Tyndall effect), and to a lesser degree this may be true for skin with dermal deposition of this pigment. The skin of the axilla is very likely to be pigmented due to deposits of homogentisic acid in sudoriferous glands in these areas.[1] The clinical features of this metabolic disorder are dark urine, pigmentation of the skin and arthritis. Particularly helpful is the almost constant presence of a patch of pigmentation (gray to brown in color) in the sclera, between the margin of the cornea and the outer or inner canthus. Because of the bluish color produced by the deep pigmentation, this condition may be confused with argyria. Early arthritis is the most common presentation of ochronosis.
See also
References
- ^ a b Collins E, Hand R (2005). "Alkaptonuric ochronosis: a case report". AANA J 73 (1): 41–46. PMID 15727283.
- ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
- ^ Bal S, Turan Y, Kocyigit H, Gurgan A, Kurtulumug S, Guvenc A (2007). "Ochronosis with cardiovascular involvement: a case report". Rheumatol Int. tbd (tbd): 479. doi:. PMID 17899092.
External links
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 | Tyrosinemia |
| Alkaptonuria |
| Saccharopinuria |
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 | Sci-Tech Dictionary. McGraw-Hill Dictionary of Scientific and Technical Terms. Copyright © 2003, 1994, 1989, 1984, 1978, 1976, 1974 by McGraw-Hill Companies, Inc. All rights reserved. Read more |
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| Medical Dictionary. The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Read more |
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| Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved. Read more |
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| WordNet. WordNet 1.7.1 Copyright © 2001 by Princeton University. All rights reserved. Read more |
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| Wikipedia. This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Ochronosis". Read more |
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