Ochronosis, often called alkaptonuric ochronosis,[1] is an autosomal recessive metabolic disorder that causes an excess of homogentisic acid, resulting in adverse pigmentation, calcification, and inflammation of cartilagenous and related tissue throughout the body.[2]:542 The disorder is a result of incomplete metabolism of homogentisic acid, tyrosine and phenylalanine. The face, skeletal system, cardiovascular system,[3] respiratory system, urinary system and to a lesser degree, the skin, are affected by this disease.There is no specific medicine invented for this disease.