Olsalazine

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Drug Info:

Olsalazine

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Brand names: Dipentum®

Chemical formula:



Olsalazine Sodium Oral capsule

What is this medicine?

OLSALAZINE (ole SAL a zeen) is used to treat ulcerative colitis. This medicine is also used to help maintain remission of the disease.
 
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
•kidney disease
•an unusual or allergic reaction to olsalazine, aspirin, other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take with food. Take your doses at regular intervals. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What may interact with this medicine?

•warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Tell your doctor or health care professional if your symptoms do not start to get better or of they get worse. It may take several weeks of treatment to achieve the full benefit. It is important that you continue taking your medicine. Do not stop taking except on the advice of your doctor or health care professional.

This medicine may cause diarrhea in some patients. Contact your doctor or health care professional if you experience any diarrhea while taking this medicine.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
•breathing problems
•chest pain
•diarrhea
•fever, chills, sore throat
•skin rash or itching
•unusual bleeding or bruising
•unusually weak or tired
•yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•muscle aches
•nausea, vomiting
•stomach pain or cramps

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

Last updated: 7/1/2002

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

5-amino-salicylate; used in the treatment of ulcerative colitis.

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Olsalazine
Systematic (IUPAC) name
5-[(2Z)-2-(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazino]-2-hydroxybenzoic acid
Clinical data
Trade names Dipentum
AHFS/Drugs.com monograph
MedlinePlus a601088
Pregnancy cat. C (US)
Legal status -only (US)
Pharmacokinetic data
Protein binding 99%
Half-life 0.9 hours
Identifiers
CAS number 15722-48-2 YesY
ATC code A07EC03
PubChem CID 6003770
DrugBank DB01250
ChemSpider 10642377 YesY
UNII ULS5I8J03O YesY
KEGG D00727 N
ChEMBL CHEMBL571540 N
Chemical data
Formula C14H10N2O6 
Mol. mass 302.239g/mol
SMILES eMolecules & PubChem
 N (what is this?)  (verify)

Olsalazine is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease such as Ulcerative Colitis. It is sold under the name Dipentum.

The chemical name is 3,3' -azobis (6-hydroxybenzoate)salicylic acid. It is sold as the disodium salt.

Like Balsalazide, Olsalazine is believed to deliver Mesalazine, or 5-aminosalicylic acid (5-ASA), past the small intestine, directly to the large intestine, which is the active site of disease in ulcerative colitis.

Contents

History

Olsalazine gained Food and Drug Administration (FDA) approval in 1990.

Supply

The drug is supplied by UCB Pharma.

Other indications

The Australian biotech company Giaconda has developed a combination therapy for treating constipation-predominant Irritable Bowel Syndrome that uses olsalazine and the anti-gout drug colchicine.

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